| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We examined the expression and involvement of IL-25, cyclophilin A, CD147, CD137, CD137L, and IL-10-producing regulatory B cells (Bregs) in cutaneous T-cell lymphoma (CTCL).
We found that Th2 cytokines highly expressed in CTCL lesional skin induced IL-25 production by epidermal keratinocytes, which may in turn lead to formation of Th2-dominant microenvironment through the direct induction of IL-13 by tumor cells. We also found that interactions between CD147 expressed on the cell surface of CTCL tumor cells and CypA secreted by those cells promote CTCL development through promoting proliferation and survival of tumor cells. Moreover, in addition to CD137, aberrant CD137L expression was found on tumor cells of CTCL, and CD137-CD137L interactions promote cell proliferation and migration in CTCL cells. Furthermore, the development of IL-10-producing Bregs is impaired in patients with advanced mycosis fungoides and the number of Bregs was inversely correlated with disease severity markers.
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