| Project/Area Number |
16K19710
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
|
|---|
| Research Institution | Teikyo University (2017)
The University of Tokyo (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 乾癬 / FTY720 / フィンゴリモド / 制御性T細胞 / イミキモド / IL-17 / IL-10 / Foxp3 |
|---|
| Outline of Final Research Achievements |
We examined whether FTY720 is effective for psoriasis using imiquimod-induced psoriasiform dermatitis mouse model. FTY720 ameliorated imiquimod-induced psoriasiform dermatitis clinically and pathological compared to control. The number of inflammatory cells was lower, and the number of regulatory T cells was higher in mice treated with FTY720 than in vehicle-treated mice. In mice treated with FTY720, expression of IL-17A and IL-17F mRNA in the affected skin was decreased, in contrast, that in inguinal lymph nodes was elevated, which suggests that FTY720 should be effective for psoriasis by hindering cells producing IL-17 from migrating from lymph nodes to the skin.
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