| Project/Area Number |
16K19716
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 類天疱瘡 / TSLP / TSLP受容体 / 好塩基球 / 水疱内好塩基球 / 水疱性類天疱瘡 |
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| Outline of Final Research Achievements |
Through FACS analysis of bullous fluid from Bullous Pemphigoid (BP) patients, we have revealed the presence of TSLP receptor (TSLPR) bearing basophils within the bullae. The bullae from BP patients were shown to contain high concentration of TSLP. Using isolated basophils from the patient bullae, we conducted an in vitro experiment to assess the production of IL-5 after stimulating these intrabullae basophils with rhTSLP. Intriguingly, large increase in IL-5 production was induced with TSLP, leading to strong speculation that TSLP interaction with the basophils in the skin lesion of BP may have strong impact on the formation of Th2 reaction which is prominently seen in BP patients.
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