| Project/Area Number |
16K19721
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SEKIGUCHI Kiyotoshi 大阪大学, 蛋白質研究所・寄附研究部門, 教授 (50187845)
MUROTA Hiroyuki 大阪大学, 医学系研究科, 准教授 (90363499)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 汗腺 / ３次元構造解析 / ホールマウント免疫染色法 / 発汗 / 収縮機構 / 3次元構造 / 分泌腺 / 筋上皮細胞 / 血管 / 神経 / 3次元構造解析 |
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| Outline of Final Research Achievements |
A whole-mount staining method was employed to visualize three-dimensional structure of human sweat gland that is unbranched coiled tubule consisting mainly of secretory portion and duct. We found that i) ductal tubule was spatially embraced in secretory tubule; ii) ductal tubule was occasionally bent, while secretory tubule was frequently bent and formed a self-entangled coiled structure; iii) secretory portion was surrounded by myoepithelial cells longitudinally elongated along entangled secretory tubules; iv) nerve fibers wrapped around secretory tubules, but not ductal tubules. These results suggest that multiple myoepithelial cells of sweat gland synchronously contract their secretory portion following innervations.
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