Development of diagnostic and therapeutic strategy for inducible uricarias
| Project/Area Number |
16K19722
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kobe University |
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Principal Investigator |
Washio Ken 神戸大学, 医学研究科, 医学研究員 (80770388)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 蕁麻疹 / コリン性蕁麻疹 / 日光蕁麻疹 / 採血検査 / 好塩基球刺激試験 / 汗アレルギー / フローサイトメトリー / アレルギー・ぜんそく / 免疫学 / じんましん / アナフィラキシー |
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| Outline of Final Research Achievements |
The investigators sought to develop the diagnostic and therapeutic strategy for inducible urticarias, especially for cholinergic and solar urticaria. During the first year, we have reported that there are specific groups of cholinergic urticaria with palpebral angioedema in which sweat allergy are responsible for disease pathophysiology. Further, we have found that the basophil activation test has higher accuracy for the diagnosis of sweat allergy than the histamine release test. We have also shown the clinical utility of basophil activation test for solar urticaria. Our findings suggested the clinical potency of blood-test based diagnosis of inducible urticarias.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Case of harlequin ichthyosis with a favorable outcome: Early treatment and novel, differentially expressed, alternatively spliced transcripts of the ATP-binding cassette subfamily A member 12 gene.2017
Author(s)
Washio K, Sumi M, Nakata K, Fukunaga A, Yamana K, Koda T, Morioka I, Nishigori C, Yamanishi.
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Journal Title
Journal of Dermatology
Volume: 印刷中
Issue: 8
Pages: 950-953
DOI
Related Report
Peer Reviewed
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