The role of neuromedin-U for mast cells activation.
| Project/Area Number |
16K19725
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hiroshima University |
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Principal Investigator |
Matsuo Yoshimi 広島大学, 医歯薬保健学研究科(医), 研究員 (50754355)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経ペプチド / ニューロメジンU / マスト細胞 / ヒスタミン / アレルギー・ぜんそく |
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| Outline of Final Research Achievements |
In this study, we investigated the effects of NMU on the activation of mouse bone marrow-derived mast cells (BMMC), connective-tissue type mouse mast cells differentiated from BMMC (CTMC), and human skin derived mast cells (HSMC) in vitro. NMU induced the degranulation of CTMC and HSMC, but not BMMC, in a concentration-dependent manner. Although no or only slight NMU receptors (NMUR1) were expressed in CTMC and HSMC, MAS-related G protein coupled receptor-X2 (MRGPRX2) and Mrgprb2, mouse analog of MRGPRX2 were highly expressed in HSMC and in CTMC, respectively, but not in BMMC at mRNA level.
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Report
(3 results)
Research Products
(5 results)
