The effect of HSP 90 inhibition for angiosarcoma
| Project/Area Number |
16K19728
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Kajihara Ikko 熊本大学, 医学部附属病院 皮膚科, 助教 (90433036)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 血管肉腫 / heat shock protein 90 / Heat shock protein 90 / 抗腫瘍効果 / HSP90 |
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| Outline of Final Research Achievements |
New therapy for angiosarcoma is urgent because there are few effective treatments. Heat shock protein 90 (HSP90) regulates cancer-associated proteins and many clinical trials of HSP90 inhibitors are on-going in several cancers. In this study, we investigated the anti-tumor effect of HSP90 inhibition. HSP90 protein are overexpressed in angiosarcoma patient’s tissues and cell lines. Knockdown of HSP90 inhibited the proliferation/migration/invasion of angiosarcoma cells. These anti-tumor effect were based on the suppression of several downstream targets of VEGF signaling. Taken together, HSP90 is a novel therapeutic target against angiosarcoma.
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| Academic Significance and Societal Importance of the Research Achievements |
血管肉腫は、非常に希少且つ悪性度が高い肉腫である。進行例では、化学療法が主体となるが、現在でも有効性の高い治療法は未確立である。そのため、血管肉腫に対する新規治療の開発は急務である。今回、HSP90阻害剤の血管肉腫に対する抗腫瘍効果を検討した。HSP90阻害効果により血管肉腫細胞株の増殖能・浸潤能・遊走能が抑制された。またその抗腫瘍効果に関する分子メカニズムを解明した。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Overexpression of cyclin-dependent kinase 4 protein in extramammary Paget's disease.2019
Author(s)
YUrata K, Kajihara I, Myangat TM, Tasaki Y, Otsuka-Maeda S, Sawamura S, Kanazawa-Yamada S, Sakamoto R, Makino K, Aoi J, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum cell-free DNA levels are a useful marker for extramammary Paget disease.2019
Author(s)
Mijiddorj T, Kajihara I, Tasaki Y, Otsuka-Maeda S, Sakamoto R, Sawamura S, Kanazawa-Yamada S, Egashira S, Inoue K, Makino K, Miyashita A, Aoi J, Igata T, Makino T, Masuguchi S, Fukushima S, Jinnin M, Morinaga J, Ikeda T, Ihn H.
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Journal Title
Br J Dermatol.
Volume: 印刷中
Related Report
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[Journal Article] Hypoxia accelerates the progression of angiosarcoma through the regulation of angiosarcoma cells and tumor microenvironment.2019
Author(s)
Maeda-Otsuka S, Kajihara I, Tasaki Y, Yamada-Kanazawa S, Sakamoto R, Sawamura S, Masuzawa M, Masuzawa M, Amoh Y, Hoshina D, Abe R, Komohara Y, Ihn H.
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Journal Title
J Dermatol Sci.
Volume: 93
Pages: 123-132
Related Report
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[Journal Article] Achieved good response of S-1 and docetaxel combination chemotherapy in two patients with metastatic extramammary Paget's disease.2017
Author(s)
Egashira S, Kajihara I, Kanemaru H, Uemura-Kiyohara M, Yamada-Kanazawa S, Nakahara S, Nagamoto E, Fukushima S, Jinnin M, Inoue Y, Ihn H.
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Journal Title
J Dermatol.
Volume: 44
Issue: 5
DOI
Related Report
Peer Reviewed
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