| Project/Area Number |
16K19731
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kagoshima University |
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Principal Investigator |
UCHIDA Youhei 鹿児島大学, 医歯学域附属病院, 講師 (30571856)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | γδT細胞 / 円形脱毛症 / TCRVδ1+γδT細胞 |
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| Outline of Final Research Achievements |
Alopecia areata (AA) is an autoimmune disease. Cytotoxic T-cells mediate premature AA HF induction. In this study, γδ T cells were detected in and around AA HFs. Terminally differentiated effector memory (CD45RA+CD27-) Vδ1 T cells significantly increases in AA patient as compared with healthy donors. CD107a is a marker of cell-activation and degranulation of cytotoxic molecule. There is a marked increase of CD107a+Vδ1 T cells in AA patient. CXCR3 and CXCR4, chemokine receptors for T-cell chemoattractant, were upregulated in AA patients. Furthermore, Vδ1 T cells has reduced expression of PD-1, a negative regulator, in AA patient. These findings suggest the cytotoxic and skin migratory ability escaping from self-tolerance of AA recruiting γδ T-cells.
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