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A new role of TCR V delta 1+ gamma delta T cells in the pathogenesis of alopecia areata

Research Project

Project/Area Number 16K19731
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKagoshima University

Principal Investigator

UCHIDA Youhei  鹿児島大学, 医歯学域附属病院, 講師 (30571856)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsγδT細胞 / 円形脱毛症 / TCRVδ1+γδT細胞
Outline of Final Research Achievements

Alopecia areata (AA) is an autoimmune disease. Cytotoxic T-cells mediate premature AA HF induction. In this study, γδ T cells were detected in and around AA HFs. Terminally differentiated effector memory (CD45RA+CD27-) Vδ1 T cells significantly increases in AA patient as compared with healthy donors. CD107a is a marker of cell-activation and degranulation of cytotoxic molecule. There is a marked increase of CD107a+Vδ1 T cells in AA patient. CXCR3 and CXCR4, chemokine receptors for T-cell chemoattractant, were upregulated in AA patients. Furthermore, Vδ1 T cells has reduced expression of PD-1, a negative regulator, in AA patient. These findings suggest the cytotoxic and skin migratory ability escaping from self-tolerance of AA recruiting γδ T-cells.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] Manchester University/Centre for Dermatology Research(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Münster University/Head of the Laboratory for Hair Research/and Regenerative Medicine(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Two cases of severe fever with thrombocytopenia syndrome virus infection.2018

    • Author(s)
      Youhei Uchida、Takuro Kanekura
    • Journal Title

      The Jounral of Dermatology

      Volume: - Issue: 5

    • DOI

      10.1111/1346-8138.14138

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 脱毛症の免疫学的病態2017

    • Author(s)
      内田洋平、Marta Bertolini、 Ralf Paus、金蔵拓郎
    • Organizer
      第47回日本皮膚アレルギー・接触皮膚炎学会総会学術大会・第41回皮膚脈管・膠原病研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Resident dermal Vdelta1+T-cells operate as autoimmunity-promoting stress-sentinels in human skin: Relevance for alopecia areata2017

    • Author(s)
      Youhei Uchida、Jennifer Gherardini, Majid Alam, Aviad Keren, Haiping Zhang, Jérémy Chéret, Akiko Arakawa, Thilo Oelert, Alfredo Rossi, Amos Gilhar, Takuro Kanekura, Marta Bertolini,and Ralf Paus
    • Organizer
      10th, World congress for hair research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 頭部の乾癬病変に生じた多毛症の一例2017

    • Author(s)
      内田洋平、金蔵拓郎
    • Organizer
      第32回日本乾癬学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 鹿児島大学病院皮膚科

    • URL

      https://com4.kufm.kagoshima-u.ac.jp/images/contents/jouhoukoukai16020128-208.pdf

    • Related Report
      2017 Annual Research Report
  • [Funded Workshop] 10th, World congress for hair research2017

    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2022-06-16  

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