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The role of Toll-like receptor 3 in the pathogenesis of immediate type hypersensitivity

Research Project

Project/Area Number 16K19734
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Nakamura Naomi  京都府立医科大学, 医学部附属病院, 研究員 (10733058)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsToll様受容体 / 即時型アレルギー / Toll様受容体3 / Toll様受容体3
Outline of Final Research Achievements

We investigated the role of TLR3 in immediate hypersensitivity in a model of IgE-dependent food anaphylaxis. Wild-type (WT), Tlr3 knockout (KO) mice were epicutaneously sensitized with ovalbumin (OVA) and then challenged orally with OVA. However, there was no significant difference in the serum levels of OVA-specific IgE antibody between OVA-sensitized WT and Tlr3 KO mice. To investigate whether Tlr3 plays a role in the skin barrier dysruption, we mesured IL-33 and TSLP in the tape-stripped mice skin. However, IL-33 and TSLP were not sigmificaly increased. In additoin, the reaction of food anaphylaxis elicited by oral OVA challenge of epicutaneous sensitized WT mice was comparative of that in Tlr3 KO mice.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation2017

    • Author(s)
      Yasuike Risa、Tamagawa-Mineoka Risa、Ueta Mayumi、Nakamura Naomi、Kinoshita Shigeru、Katoh Norito
    • Journal Title

      Journal of Dermatological Science

      Volume: 88 Issue: 2 Pages: 184-191

    • DOI

      10.1016/j.jdermsci.2017.07.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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