| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Author revealed that extracellular ATP expresses psoriasis-related gene cluster such as EGF family, PTGS2 and IL-33 in human skin three-dimensional model. Furthermore, author demonstrated that time-dependent activation of Ras-ERK and PI3K-Akt pathway in downstream of EGF family receptor. Author next focused these intracellular signal transduction pathways on the effect of ATP treatment on the protein expression of the PTGS2. As the result, time-dependent expression of PTGS2 by ATP treatment of human skin three-dimensional model. These results suggest that activation of Ras-ERK or PI3K-Akt pathway may be involved in ATP-induced PTGS2. It is conceivable that the finding that extracellular ATP regulates these intracellular signal transductions is important for pathogenesis and therapeutic strategy of psoriasis.
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