Functional analysis of extracellular ATP in psoriasis
Project/Area Number |
16K19736
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | Ohu University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 尋常性乾癬 / 細胞外ATP / EGFファミリー / PTGS2 / Ras-ERK経路の活性化 / PI3K-AKT経路の活性化 / IL-33 / 免疫学 / マイクロアレイ |
Outline of Final Research Achievements |
Author revealed that extracellular ATP expresses psoriasis-related gene cluster such as EGF family, PTGS2 and IL-33 in human skin three-dimensional model. Furthermore, author demonstrated that time-dependent activation of Ras-ERK and PI3K-Akt pathway in downstream of EGF family receptor. Author next focused these intracellular signal transduction pathways on the effect of ATP treatment on the protein expression of the PTGS2. As the result, time-dependent expression of PTGS2 by ATP treatment of human skin three-dimensional model. These results suggest that activation of Ras-ERK or PI3K-Akt pathway may be involved in ATP-induced PTGS2. It is conceivable that the finding that extracellular ATP regulates these intracellular signal transductions is important for pathogenesis and therapeutic strategy of psoriasis.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] 先発・後発輸液製剤の物理化学的性質に関する検討(第2報)―糖加電解質輸液(3号液)に関する検討―2017
Author(s)
武井佐和子, 大原宏司, 影山美穂, 戸張裕子, 別生伸太郎, 濱田真向, 増田多加子, 大山勝宏, 勝山壮, 井上みち子, 倉本 敬二
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Journal Title
日本注射薬臨床情報学会誌
Volume: 6
Pages: 25-35
Related Report
Peer Reviewed
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