| Project/Area Number |
16K19740
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Kiso Masahiro 国立研究開発法人国立国際医療研究センター, その他部局等, 医師 (20769517)
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| Co-Investigator(Renkei-kenkyūsha) |
YABE Shigeharu 国立国際医療研究センター, 細胞組織再生医学研究部, 上級研究員 (40533716)
Okochi Hitoshi 国立国際医療研究センター, 細胞組織再生医学研究部, 部長 (30185235)
ITOH Munenari 東京慈恵医科大学, 皮膚科学講座, 講師 (20408371)
NAKAGAWA Hidemi 東京慈恵医科大学, 皮膚科学講座, 教授 (20114580)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 毛乳頭細胞 / 毛包再生 / TERT遺伝子 / BMI1遺伝子 / 不死化 / Bmi1遺伝子 / 毛包再構築実験 / 毛包誘導能 |
|---|
| Outline of Final Research Achievements |
It is reported that dermal papilla cells are necessary for regeneration of hair follicles since hair follicle is induced at the palm pad area, when dermal papilla cells (DPCs) were transplanted into a hairless area. However, once DPCs are cultured under two-dimension culture, the ability of proliferate and hair inductive activity are quickly lost. In this study, we clearly showed that murine and human DPCs induced by TERT and BMI1 restored their growth potential and characteristics as DPs in terms of the hair inductive activity. These DPCs are seems to be attractive as great tools to investigate the precise mechanism of maintaining hair inductive activity.
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