Therapiutic effects of mesenchymal stem cells (MSCs) for dermatitis
| Project/Area Number |
16K19741
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANISHI Kiyofumi 兵庫医科大学, 医学部, 教授 (10182586)
IMAI Yasutomo 兵庫医科大学, 医学部, 講師 (10529514)
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| Research Collaborator |
JITSUKAWA Orie 兵庫医科大学, 医学部, 実験補助
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MSC / 間葉系幹細胞 / 尋常性乾癬 / 免疫学 / 乾癬 / 皮膚炎 |
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| Outline of Final Research Achievements |
Cell-based therapies using mesenchymal stem cells (MSCs) are emerging as a treatment strategy of intractable inflammatory disorders. The therapeutic effect of MSCs on psoriatic dermatitis (PsD) has been tested; the effect of MSC-conditioned medium (MSC-CM) on chemokine production was tested in cultured normal human epidermal keratinocytes (NHEK). Interestingly, MSC-CM significantly reduced IL-8 production induced by IFNγ or TNF-α in NHEK. Hence, MSCs might be beneficial for treatment of psoriasis and clinical trial for psoriasis will help elucidate the efficacy of cell-based therapy using MSCs.
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Report
(3 results)
Research Products
(12 results)
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[Presentation] 局所麻酔手術の周術期管理2016
Author(s)
伊藤 孝明, 中川 登, 永井 諒, 井上 裕香子, 草壁 みのり, 和田 吉弘, 山本 雅章, 羽田 孝司, 夏秋 優, 山西 清文
Organizer
局所麻酔手術の周術期管理. 第31回日本皮膚外科学会総会・学術集会
Place of Presentation
プラザヴェルデ（静岡県,沼津市)
Year and Date
2016-09-10
Related Report
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