| Project/Area Number |
16K19741
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Hyogo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMANISHI Kiyofumi 兵庫医科大学, 医学部, 教授 (10182586)
IMAI Yasutomo 兵庫医科大学, 医学部, 講師 (10529514)
|
|---|
| Research Collaborator |
JITSUKAWA Orie 兵庫医科大学, 医学部, 実験補助
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | MSC / 間葉系幹細胞 / 尋常性乾癬 / 免疫学 / 乾癬 / 皮膚炎 |
|---|
| Outline of Final Research Achievements |
Cell-based therapies using mesenchymal stem cells (MSCs) are emerging as a treatment strategy of intractable inflammatory disorders. The therapeutic effect of MSCs on psoriatic dermatitis (PsD) has been tested; the effect of MSC-conditioned medium (MSC-CM) on chemokine production was tested in cultured normal human epidermal keratinocytes (NHEK). Interestingly, MSC-CM significantly reduced IL-8 production induced by IFNγ or TNF-α in NHEK. Hence, MSCs might be beneficial for treatment of psoriasis and clinical trial for psoriasis will help elucidate the efficacy of cell-based therapy using MSCs.
|
