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Elucidation of the mechanism of apoptosis resistance and the metabolic pathway required for cutaneous T-cell lymphoma

Research Project

Project/Area Number 16K19743
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKurume University

Principal Investigator

HASHIKAWA keiko  久留米大学, 医学部, 講師 (00368929)

Research Collaborator NAKAMA takekuni  
OHATA chika  
KARASHIMA tadashi  
ISHII norito  
OHYAMA bungo  
NATSUAKI youhei  
OHSHIMA koichi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsリンパ腫 / 皮膚腫瘍 / アポトーシス / 代謝経路
Outline of Final Research Achievements

Cutaneous T-cell lymphoma (CTCL) is thought to escape immune surveillance and gain apoptosis resistance, and gradually advance stage of disease. However the mechanism of apoptosis resistance in CTCL remains unclear. In this study, 27 tissue samples of mycosis fungoides, which is the most common form of CTCL, 18 samples of Adult T-cell leukemia/lymphoma, which caused by human malignancy associated with human T-cell lymphotropic virus-type I and 34 controls were available. Each clinical and histopathological feature was surveyed. We performed immunohistochemical analysis related c-CBL E3 Ubiquitin Ligase expression, which is associated with apoptosis in CTCL. To analyze expressions precisely, we constructed tissue microarray, which take a core of the specimen from each donor tissue block and are arranged on a recipient paraffin block. Immunohistochemical analysis was performed on constructed TMA for CD47 and signal regulatory protein α. We are currently analyzing these results.

Academic Significance and Societal Importance of the Research Achievements

菌状息肉症は皮膚悪性リンパ腫のうち最多だが発症頻度は人口100万人当たり約10人で、十分に病態解明されていない。炎症性疾患との鑑別は臨床的・組織学的に類似点も多く容易と言えず早期の確定診断が困難なことも多い。紅斑期から次第に扁平浸潤期を経て腫瘤期と進行するため、病態解明により紅斑期の診断精度が向上することや治療開発は重要である。リンパ腫細胞の生存に必要な代謝経路やアポトーシス抵抗性の機構解明によって、病初期の確定診断や代謝経路阻害・アポトーシス促進という新規治療、たとえばB細胞リンパ腫でのCD47阻害薬とリツキシマブの併用のような既存治療との併用での相乗効果が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (3 results)

  • [Journal Article] 症例報告 メトトレキサート関連リンパ増殖異常症の1例-過去の報告例の集計を添えて2018

    • Author(s)
      永田 寛、橋川 恵子、猿田 寛、石井 文人、長藤 宏司、大島 孝一、名嘉眞 武国
    • Journal Title

      臨床皮膚科

      Volume: 72 Issue: 4 Pages: 347-354

    • DOI

      10.11477/mf.1412205362

    • NAID

      40021545700

    • ISSN
      0021-4973, 1882-1324
    • Year and Date
      2018-04-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 足趾の皮膚病 臨床例 完全消褪したinfantile digital fibromatosis2018

    • Author(s)
      矢野 有紗・橋川 恵子・大畑 千佳・小野 文武・名嘉眞 武国
    • Journal Title

      皮膚病診療

      Volume: 40 Issue: 4 Pages: 381-384

    • DOI

      10.24733/J01268.2018219075

    • ISSN
      0387-7531
    • Year and Date
      2018-04-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] IgG4関連疾患患者に生じた下腿潰瘍の1例2017

    • Author(s)
      橋川恵子, 石井文人, 名嘉眞武国, 廣松伸一, 岡部義信
    • Organizer
      第40回 皮膚脈管・膠原病研究会
    • Place of Presentation
      コラッセふくしま(福島市)
    • Year and Date
      2017-01-20
    • Related Report
      2016 Research-status Report
  • [Presentation] IgG4関連疾患患者に生じた下腿潰瘍の1例2017

    • Author(s)
      橋川恵子・石井文人・廣松伸一・岡部義信・名嘉眞武国
    • Organizer
      第40回 皮膚脈管・膠原病研究会
    • Related Report
      2017 Research-status Report
  • [Book] WHO血液腫瘍分類 : WHO分類2017をうまく活用するため(P312-P314, P333-P336, P345-P346, P348-P350)2018

    • Author(s)
      橋川恵子, 大島孝一
    • Total Pages
      463
    • Publisher
      医薬ジャーナル社
    • ISBN
      9784753228713
    • Related Report
      2018 Annual Research Report
  • [Book] WHO血液腫瘍分類 : WHO分類2017をうまく活用するために(P356-P358)2018

    • Author(s)
      新野大介, 大島孝一, 橋川恵子
    • Total Pages
      463
    • Publisher
      医薬ジャーナル社
    • ISBN
      9784753228713
    • Related Report
      2018 Annual Research Report
  • [Book] 治療(皮膚のコモンディジーズとそのピットフォール~ホクロとメラノーマ~)2017

    • Author(s)
      名嘉眞武国, 橋川恵子
    • Publisher
      南山堂
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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