Anti-inflammatory effect of Maresin 1 on skin inflamation

Research Project

Project/Area Number	16K19744
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	University of Occupational and Environmental Health, Japan
Principal Investigator	SAWADA Yu 産業医科大学, 医学部, 講師 (40551867)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Maresin 1 / 乾癬 / IL-23 / IL-17 / 免疫学
Outline of Final Research Achievements	To examine anti-inflammatory effect of maresin 1 on skin inflammation, we used imiquimod-induced psoriasis model. Maresin 1 attenuates imiquimod-induced skin inflammation through regulating IL-17A production by γδT cell and Th17 cell. Maresin 1 downmodulates IL-23 receptor expression on these cells by RoRγt and IL-23 receptor internalization. Therefore, our results show maresin 1 inhibits imiquimod-induced skin inflammation through these mechanises. We plan to analyze additional anti-inflammatory effect of maresin 1 on other skin inflammatory disease models.

Report

(3 results)