Research on the pathophysiology of attention deficit based on glial cell line-derived neurotrophic factor

• Project/Area Number: 16K19750
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Chiba University
• Principal Investigator: Niitsu Tomihisa 千葉大学, 大学院医学研究院, 講師 (90456054)
• Research Collaborator: Iyo Masaomi ; Hashimoto Kenji ; Hashimoto Tasuku ; Sasaki Tsuyoshi ; Oda Yasunori ; Kimura Atsushi ; Hata Tatsuki ; Idemoto Keita
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: グリア細胞株由来神経栄養因子 / 注意欠陥多動性障害 / 気分障害 / うつ病 / 双極性障害 / 注意障害 / 大うつ病性障害 / バイオマーカー / 注意欠如・多動性障害 / 脳神経疾患

Outline of Final Research Achievements

Serum levels of glial cell line-derived neurotrophic factor (GDNF) were associated with severity of attention deficits in adult patients with attention deficits/hyperactivity disorder (ADHD). Decreased serum levels of GDNF were associated with severity of mood disorders, major depressive disorder and bipolar disorder. Serum levels of GDNF may be a potential biomarker for ADHD and mood disorders.

Academic Significance and Societal Importance of the Research Achievements

注意障害は多くの精神疾患に共通して認められる。そのため、注意障害は精神疾患患者の日常生活や就労に大きな影響を与えており、社会経済的影響も大きい障害といえる。今回の研究成果は、グリア細胞株由来神経栄養因子（GDNF）が注意欠陥多動性障害（ADHD）や気分障害の病態に関連していることを見出した。今後、GDNFに基づいたADHDや気分障害の病態解明および治療法の開発へつながることが期待される。

Research Products

• [Presentation] Serum levels of glial cell line-derived neurotrophic factor (GDNF) are associated with severity and lithium-resistance in bipolar disorder (2019)
  • Author(s): Keita Idemoto, Tomihisa Niitsu, Tatsuki Hata, Yasunori Oda, Atsushi Kimura, Tasuku Hashimoto, Kenji Hashimoto, Masaomi Iyo
  • Organizer: The 21th annual ISBD conference: Global advances in bipolar disorder and depression, 20-23 March 2019, ICC Sydney
  • Int'l Joint Research
• [Presentation] 気分障害のバイオマーカーとしての血清中グリア細胞株由来神経栄養因子（GDNF）の検討 (2018)
  • Author(s): 井手本啓太、新津富央、畑達記、木村敦史、小田靖典、橋本佐、橋本謙二、伊豫雅臣
  • Organizer: 第45回日本脳科学会、2018年11月10-11日、千葉
• [Presentation] Serum levels of glial cell line-derived neurotrophic factor in adult patients with attention deficit/hyperactivity disorder (2017)
  • Author(s): Niitsu T, Oda Y, Hata T, Sasaki T, Hashimoto K, Iyo M
  • Organizer: 第44回日本脳科学会