Research on the pathophysiology of attention deficit based on glial cell line-derived neurotrophic factor
| Project/Area Number |
16K19750
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Chiba University |
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Principal Investigator |
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| Research Collaborator |
Iyo Masaomi
Hashimoto Kenji
Hashimoto Tasuku
Sasaki Tsuyoshi
Oda Yasunori
Kimura Atsushi
Hata Tatsuki
Idemoto Keita
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | グリア細胞株由来神経栄養因子 / 注意欠陥多動性障害 / 気分障害 / うつ病 / 双極性障害 / 注意障害 / 大うつ病性障害 / バイオマーカー / 注意欠如・多動性障害 / 脳神経疾患 |
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| Outline of Final Research Achievements |
Serum levels of glial cell line-derived neurotrophic factor (GDNF) were associated with severity of attention deficits in adult patients with attention deficits/hyperactivity disorder (ADHD). Decreased serum levels of GDNF were associated with severity of mood disorders, major depressive disorder and bipolar disorder. Serum levels of GDNF may be a potential biomarker for ADHD and mood disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
注意障害は多くの精神疾患に共通して認められる。そのため、注意障害は精神疾患患者の日常生活や就労に大きな影響を与えており、社会経済的影響も大きい障害といえる。今回の研究成果は、グリア細胞株由来神経栄養因子（GDNF）が注意欠陥多動性障害（ADHD）や気分障害の病態に関連していることを見出した。今後、GDNFに基づいたADHDや気分障害の病態解明および治療法の開発へつながることが期待される。
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Report
(4 results)
Research Products
(3 results)
