| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Expression of Myelin Oligodendrocyte Glycoprotein (MOG) and thickness of MOG-positive fiber-like structures were decreased in the superior temporal gyrus and the CA3 of hippocampus of the long-term schizophrenic brains. These findings suggest that oligodendrocyte- myelin abnormalities in these regions may be related to the pathophysiology of schizophrenia.
In also schizophrenic brains with rare variants (22q11.2 deletion, GLO1 frameshift mutation), morphological alternation of proteins associated with oligodendrocytes-myelin (MOG, Nogo-A) were observed. These findings contribute to understanding of relationship between pathological phenotype and molecular biological backgrounds.
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