| Project/Area Number |
16K19764
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka University |
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Principal Investigator |
KONDO Makoto 大阪大学, 医学系研究科, 准教授 (50633012)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | うつ病 / 運動 / セロトニン受容体 / 海馬神経新生 / 海馬の神経新生 / 抗うつ効果 |
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| Outline of Final Research Achievements |
Although selective serotonin reuptake inhibitors (SSRIs) are the most widely used antidepressants, a significant proportion of depressed patients do not achieve remission with SSRIs. Therefore, development of novel antidepressants is highly desirable. Exercise provides neurogenic and antidepressant effects, and we recently demonstrated that the serotonin type 3 (5HT3) receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. In this study, we revealed that treatment of 5HT3 receptor agonist induces antidepressant effects as well as hippocampal neurogenesis independent of SSRIs. Furthermore, we found that 5HT3 receptor-dependent increased IGF1 in the hippocampus is important for neurogenesis and antidepressant effects. Our findings suggest that a novel 5HT3 receptor-IGF1 mechanism could provide a new therapeutic target for depression, based on the mechanism of exercise-induced antidepressant effects.
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