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Peripheral gene expression-based biological test for psychiatric diseases

Research Project

Project/Area Number 16K19769
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionThe University of Tokushima

Principal Investigator

WATANABE Shin-ya  徳島大学, 大学院医歯薬学研究部(医学系), 助教 (90563825)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords診断マーカー / うつ病 / 遺伝子発現 / 末梢血白血球 / 統合失調症 / 双極性障害 / 白血球 / PCRarray / 遺伝子
Outline of Final Research Achievements

We measured messenger ribonucleic acid expression levels of the aforementioned five genes in peripheral leukocytes in 17 patients with schizophrenia and 36 patients with bipolar disorder using quantitative real-time polymerase chain reaction (PCR), and we combined these expression data with our previous expression data of 25 patients with MDD and 25 controls. Subsequently, a linear discriminant function was developed for use in discriminating between patients with MDD and without MDD.This expression panel was able to segregate patients with MDD from those without MDD with a sensitivity and specificity of 64% and 67.9%, respectively.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Gene expression-based biological test for major depressive disorder; an advanced study2017

    • Author(s)
      Watanabe S, Numata S, Iga J, Kinoshita M, Umehara H, Ishii K, Ohmori T
    • Journal Title

      Neuropsychiatr Dis Treat.

      Volume: 13 Pages: 535-541

    • DOI

      10.2147/ndt.s120038

    • NAID

      120006999399

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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