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Brain imaging study of neural activity of auditory hallucination in schizophrenia

Research Project

Project/Area Number 16K19772
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

Nakamura Itta  九州大学, 医学研究院, 共同研究員 (90771460)

Research Collaborator ONITSUKA TOSHIAKI  九州大学, 医学研究院, 准教授 (00398059)
HIRANO YOJI  九州大学, 医学研究院, 助教 (90567497)
UENO TAKEFUMI  肥前精神医療センター, 臨床研究部長 (00441668)
ORIBE NAOYA  肥前精神医療センター, 脳生理・神経画像, 研究室員 (70730498)
KUGA HIRONORI  ジョン-ホプキンス大学, 医学研究院 (50639903)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords統合失調症 / 幻聴 / γ帯域活動 / 脳磁図 / 聴性定常反応 / ガンマ帯域活動 / neural oscillation / 精神医学
Outline of Final Research Achievements

Auditory hallucination is one of the main symptoms of schizophrenic disorder and strong association with social life dysfunction has been shown. Many studies mentioned correlation with the degree of auditory hallucination symptoms and various auditory stimulus-inducing components in schizophrenia, while brain activities related to the start and end of hallucination of schizophrenic patients with intermittent hallucinations have not been cleared yet.
In this study, we investigated the immediate change of spontaneous brain activity and gamma band auditory steady-state response (ASSR), and found the possibility that the early component of ASSR varies depending on the presence or absence of auditory hallucination experience. In the future, considering further examination with a large sample, it is thought that it will lead to elucidation of the pathological condition related to the occurrence of the auditory experience.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Right hemisphere pitch-mismatch negativity reduction in patients with major depression: An MEG study.2017

    • Author(s)
      Hirakawa N, Hirano Y, Nakamura I, Hirano S, Sato J, Oribe N, Ueno T, Kanba S, Onitsuka T.
    • Journal Title

      J Affect Disord.

      Volume: 215 Pages: 225-229

    • DOI

      10.1016/j.jad.2017.03.046

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Right hemisphere pitch-mismatch negativity reduction in patients with major depression: An MEG study.2017

    • Author(s)
      Noriaki Hirakawa, Yoji Hirano, Itta Nakamura, Shogo Hirano, Jinya Sato, Naoya Oribe, Takefumi Ueno, Shigenobu Kanba, and Toshiaki Onitsuka
    • Journal Title

      J Affect Disord

      Volume: 215 Pages: 225-229

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia.2016

    • Author(s)
      Hironori Kuga, Toshiaki Onitsuka, Yoji Hirano, Itta Nakamura, Naoya Oribe, Hiroaki Mizuhara, Ryota Kanai, Shigenobu Kanba, and Takefumi Ueno
    • Journal Title

      EBioMedicine

      Volume: 12 Pages: 143-149

    • NAID

      120005997816

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 統合失調症者の視聴覚統合機能異常:脳磁図研究2017

    • Author(s)
      中村一太
    • Organizer
      第3回Psychiatry Neuroscience Seminar: 佐賀県
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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