Increase glial glutamate release couse to depression in rat model

• Project/Area Number: 16K19774
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: University of Miyazaki
• Principal Investigator: ebihara kosuke 宮崎大学, 医学部, 助教 (20510720)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: グリア / 光遺伝学 / ICSS / 精神医学 / 行動科学

Outline of Final Research Achievements

I had negative results in this plan of experiment. I tried to discuss about some problem in this work. Maybe it is wrong potion in rat brain or method. Glutamine nerves are rich in prefrontal cortex. so aiming the point. but Glutamate receptor are beyond nerve endings, amygdala, including limbic system. Probably, Optogenetically stimulating amygdala increase glutamete and couse to beanhedonia in rat model.

Research Products

• [Presentation] 光遺伝学的手法を用いたうつ病グリアモデルの検討 (2017)
  • Author(s): 蛯原 功介
  • Organizer: 日本生物学的精神医学会