Increase glial glutamate release couse to depression in rat model

Research Project

Project/Area Number	16K19774
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	University of Miyazaki
Principal Investigator	ebihara kosuke 宮崎大学, 医学部, 助教 (20510720)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	グリア / 光遺伝学 / ICSS / 精神医学 / 行動科学
Outline of Final Research Achievements	I had negative results in this plan of experiment. I tried to discuss about some problem in this work. Maybe it is wrong potion in rat brain or method. Glutamine nerves are rich in prefrontal cortex. so aiming the point. but Glutamate receptor are beyond nerve endings, amygdala, including limbic system. Probably, Optogenetically stimulating amygdala increase glutamete and couse to beanhedonia in rat model.

Report

(3 results)