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Effect of oxytocin nasal spray on auditory automatic discrimination measured by mismatch negativity

Research Project

Project/Area Number 16K19777
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionFukushima Medical University

Principal Investigator

Shiga Tetsuya  福島県立医科大学, 医学部, 准教授 (90612713)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsミスマッチ陰性電位 / 事象関連電位 / オキシトシン / 統合失調症 / 精神神経科学 / 精神生理学
Outline of Final Research Achievements

To determine whether oxytocin nasal spray affects auditory MMN, we measured ERPs in healthy subjects and schizophrenia patients during an auditory oddball task, both as a baseline and after administration.
Forty healthy subjects were randomly assigned to either oxytocin or placebo groups. ERPs were recorded during the oddball task for all subjects before and after an intranasal administration, and MMN was compared between the two groups.
Participants who received oxytocin had significantly shorter MMN latencies than those who received a placebo. No MMN amplitude was observed in either group. The shortened MMN latencies after oxytocin nasal spray suggest that oxytocin may promote the comparison-decision stage. We also recorded the same oddball task for schizophrenia patients who randomly assigned to either oxytocin or placebo groups. As a result, there were no significant difference of MMN between oxytocin and placebo groups in schizophrenia.

Academic Significance and Societal Importance of the Research Achievements

進行性に認知機能低下をきたす統合失調症において、近年オキシトシン点鼻薬による治療が患者の社会機能、表情認知、臭覚識別機能を改善させるという報告がある。一方で、自動的聴覚識別機能を反映するミスマッチ陰性電位(MMN)は、この疾患の認知機能低下を鋭敏に反映することが知られている。
本研究の結果から、オキシトシン点鼻治療薬が健常者において、上記のような効果のみならず、聴覚識別反応にも促進的に作用する可能性が示唆された。しかし、統合失調症患者においてはその効果が認められなかった。本家級の結果は、今後のオキシトシン点鼻薬の応用に利用可能かもしれない。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2017 2016

All Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 統合失調症の認知機能障害に対するオキシトシン点鼻薬の効果2019

    • Author(s)
      落合晴香、志賀哲也、菅野和子、星野大、和田知紘、刑部有祐、堀越翔、三浦至、 矢部博興
    • Organizer
      第49回日本臨床神経生理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 統合失調症者の聴覚自動識別機能に対するオキシトシン点鼻薬の効果2019

    • Author(s)
      落合晴香、菅野和子、星野大、和田知紘、刑部有祐、堀越翔、志賀哲也、三浦至、 矢部博興
    • Organizer
      第22回日本薬物脳波学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of oxytocin on mismatch negativity in healthy subjects2018

    • Author(s)
      Haruka Ochiai, Tetsuya Shiga, Kazuko Kanno, Hiroshi Hoshino, Tomohiro Wada, Yusuke Osakabe, Sho Horikoshi, Itaru Miura, Hirooki Yabe
    • Organizer
      The 8th Mismatch Negativity conference (MMN2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 健常者においてオキシトシンがミスマッチ陰性電位に与える影響についての検討2017

    • Author(s)
      落合晴香、菅野和子、星野大、堀越翔、志賀哲也、三浦至、矢部博興
    • Organizer
      第20回日本薬物脳波学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 健常者のミスマッチ陰性電位に与えるオキシトシンの影響についての検討2017

    • Author(s)
      落合晴香,菅野和子,星野大,和田知紘,刑部有祐,堀越翔, 志賀哲也,三浦至,矢部博興
    • Organizer
      第47回日本臨床神経生理学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] オキシトシン点鼻治療によるミスマッチ陰性電位の効果の検討;preliminary study2016

    • Author(s)
      落合晴香、菅野和子、星野大、堀越翔、志賀哲也、三浦至、矢部博興
    • Organizer
      第19回日本薬物脳波学会
    • Place of Presentation
      沖縄県宮古島市
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-01-27  

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