| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Dysfunction of Rev-erbα, a core circadian clock gene, has been associated with Pathogenesis of affective disorder including bipolar disorder. However, detailed molecular mechanisms remain unclear. In this study, we found dysregulation of serotonergic system in Rev-erbα knockout mice. Despite a reduction in genes expression of key enzymes of serotonin synthesis, knockout mice show normal levels of serotonin and its metabolite in the dorsal raphe nuclei. However, prefrontal cortex, an important target of serotonin, shows the reduction of serotonin levels in knockout animals. These results indicate that serotonin release is impaired in Rev-erbα knockout mice. In addition, the expression of genes related to neuronal activity was decreased in the prefrontal cortex of Rev-erbα knockout mice. Therefore, we have concluded that defect in Rev-erbα may play an important role in organizing the serotonergic system in mammals.
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