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Validation of clinical symptoms and objective indicators for non-invasive brain stimulation for schizophrenia

Research Project

Project/Area Number 16K19787
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionKansai Medical University

Principal Investigator

IKEDA SHUNICHIRO  関西医科大学, 医学部, 助教 (40772231)

Research Collaborator Nishida Keiichiro  
Yoshimura Masafumi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords統合失調症 / 経頭蓋直流電気刺激法 / tDCS / 経頭蓋直流刺激 / Schizophrenia / tdcs / 脳神経疾患 / 医療・福祉 / 電気生理、精神生理学 / 精神神経科学 / 経頭蓋直流電気刺激
Outline of Final Research Achievements

In recent years, transcranial direct current stimulation (tDCS) has attracted attention, and in this study, the purpose was to examine the effectiveness and safety of tDCS for cognitive dysfunction in schizophrenia and psychotic symptoms and to construct the evidence for clinical application.
We also conducted research on patients with depression and presented at domestic and international conferences. I made three papers as a lead author and made a paper as a co-author mainly on Clinical EEG and Neuroscience and Clinical Neurophysiology etc. As a result, the effect of tDCS on schizophrenia is limited, and it has been found that it is an experimental stage, and it is necessary to further accumulate cases and experiences.

Academic Significance and Societal Importance of the Research Achievements

近年、経頭蓋直流電気刺激法(tDCS)は注目されているが、その理由は他のニューロモデュレーションと比較して低侵襲であり安全性が高く安価である点である。しかし、うつ病に対してエビデンスは徐々に構築できているものの、統合失調症に対するtDCSの効果の実証については、不十分である。本研究では、統合失調症の認知機能障害、精神病症状に対するtDCSの有効性、安全性の検証を行った。このエビデンスを構築することで臨床応用が可能になる可能性もあり意義深い。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2019 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 10 results,  Open Access: 7 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Automated Source Estimation of Scalp EEG Epileptic Activity Using eLORETA Kurtosis Analysis2019

    • Author(s)
      Ikeda Shunichiro、Ishii Ryouhei、Pascual-Marqui Roberto?D.、Canuet Leonides、Yoshimura Masafumi、Nishida Keiichiro、Kitaura Yuichi、Katsura Koji、Kinoshita Toshihiko
    • Journal Title

      Neuropsychobiology

      Volume: 77 Issue: 2 Pages: 101-109

    • DOI

      10.1159/000495522

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Changes of clinical symptoms in patients with new psychoactive substance (NPS)-related disorders from fiscal year 2012 to 2014: A study in hospitals specializing in the treatment of addiction.2019

    • Author(s)
      Funada D, Matsumoto T, Tanibuchi Y, Kawasoe Y, Sakakibara S, Naruse N, Ikeda S, Sunami T, Muto T, Cho T
    • Journal Title

      Neuropsychopharmacol Rep

      Volume: 2019 Issue: 2 Pages: 1-11

    • DOI

      10.1002/npr2.12053

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alpha event‐related synchronization after eye closing differs in Alzheimer’s disease and dementia with Lewy bodies: a magnetoencephalography study2018

    • Author(s)
      Masahiro Hata Ryu Kurimoto Hiroaki Kazui Ryouhei Ishii Leonides Canuet Yasunori Aoki Shunichiro Ikeda Shingo Azuma Takashi Suehiro Shunsuke Sato Yukiko Suzuki Hideki Kanemoto Kenji Yoshiyama Masao Iwase Manabu Ikeda
    • Journal Title

      Psychogeriatrics

      Volume: Feb 8. Issue: 3 Pages: 202-208

    • DOI

      10.1111/psyg.12313

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyperactivation of the Frontal Control Network Revealed by Symptom Provocation in Obsessive-Compulsive Disorder Using EEG Microstate and sLORETA Analyses.2018

    • Author(s)
      Yoshimura M, Pascual-Marqui RD, Nishida K, Kitaura Y, Mii H, Saito Y, Ikeda S, Katsura K, Ueda S, Minami S, Isotani T, Kinoshita T
    • Journal Title

      Neuropsychobiology

      Volume: 77 Pages: 176-185

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Healthy and Pathological Brain Aging: From the Perspective of Oscillations, Functional Connectivity, and Signal Complexity.2017

    • Author(s)
      Ishii R, Canuet L, Aoki Y, Hata M, Iwase M, Ikeda S5 Nishida K5 Ikeda M.
    • Journal Title

      Neuropsychobiology

      Volume: 75(4) Issue: 4 Pages: 151-161

    • DOI

      10.1159/000486870

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Source estimation of epileptic activity using eLORETA kurtosis analysis.2017

    • Author(s)
      Ikeda S, Ishii R, Canuet L, Pascual-Marqui RD.
    • Journal Title

      BMJ Case Rep

      Volume: Nov 16 Pages: 222123-222123

    • DOI

      10.1136/bcr-2017-222123

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional localization and effective connectivity of cortical theta and alpha oscillatory activity during an attention task2017

    • Author(s)
      Yuichi Kitaura, Keiichiro Nishida, Masafumi Yoshimura, Hiroshi Mii, Koji Katsura, Satsuki Ueda, Shunichiro Ikeda, Roberto D. Pascual-Marqui, Ryouhei Ishii, Toshihiko Kinoshita
    • Journal Title

      Clinical Neurophysiology Practice

      Volume: Volume 2 Pages: 193-200

    • DOI

      10.1016/j.cnp.2017.09.002

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The cross-frequency mediation mechanism of intracortical information transactions2017

    • Author(s)
      RD Pascual-Marqui, P Faber, S Ikeda, R Ishii, T Kinoshita, Y Kitaura, K Kochi, P Milz, K Nishida, M Yoshimura
    • Journal Title

      Neurons and Cognition

      Volume: Mar Pages: 07654-07654

    • DOI

      10.1101/119362

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Correlate With Electroencephalography Parameters Assessed by Exact Low-Resolution Electromagnetic Tomography (eLORETA).2016

    • Author(s)
      Hata M, Tanaka T, Kazui H, Ishii R, Canuet L, Pascual-Marqui RD, Aoki Y, Ikeda S, Sato S, Suzuki Y, Kanemoto H, Yoshiyama K, Iwase M.
    • Journal Title

      Clinical EEG and Neuroscience

      Volume: aug Issue: 5 Pages: 338-347

    • DOI

      10.1177/1550059416662119

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional connectivity assessed by resting state EEG correlates with cognitive decline of Alzheimer's disease - An eLORETA study.2016

    • Author(s)
      Hata M, Kazui H, Tanaka T, Ishii R, Canuet L, Pascual-Marqui RD, Aoki Y, Ikeda S, Kanemoto H, Yoshiyama K, Iwase M, Takeda M.
    • Journal Title

      Clin Neurophysiol.

      Volume: 127(2) Issue: 2 Pages: 1269-78

    • DOI

      10.1016/j.clinph.2015.10.030

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 【臨床神経生理学が精神疾患の治療において果たす役割―update-】精神疾患におけるマイクロステート解析の有用性.2018

    • Author(s)
      池田俊一郎
    • Organizer
      第48回日本臨床神経生理学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] The neurophysiological connectivity changing in patients with depression is depends on the anodal stimulation area2017

    • Author(s)
      Keiichiro Nishida
    • Organizer
      Second International Brain Stimulation Conference
    • Place of Presentation
      HOTEL Hesperia Tower
    • Year and Date
      2017-03-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The neurophysiological connectivity changing in patients with depression is depends on the anodal stimulation area2017

    • Author(s)
      K. Nishida, R. Pascual-Marqui, M. Yoshimura, S. Ikeda, S. Ueda, Y. Koshikawa, A. Onohara, K. Katsura, R. Ishi, T. Kinoshita
    • Organizer
      Brain stimulation 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] eLORETAを用いたてんかん性異常波の発生源推定による脳波検査自動解析機能への展望2016

    • Author(s)
      池田俊一郎
    • Organizer
      第19回薬物脳波学会
    • Place of Presentation
      ホテルブリーズベイマリーナ(沖縄)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳波による情動の脳内処理過程の定量的評価2016

    • Author(s)
      池田俊一郎
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      ホテルハマツ(福島)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 精神疾患におけるtDCS(transcranial direct current stimulation)の効果 ─ うつ病を中心に ─2016

    • Author(s)
      西田圭一郎
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      ホテルハマツ(福島)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] Ⅲ疾患別各論 E内科関連の神経疾患 9心身症.神経疾患最新の治療 2018-20202018

    • Author(s)
      1.池田俊一郎,木下利彦
    • Total Pages
      376
    • Publisher
      南江堂
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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