Associations between central glutamatergic neurotransmission and cognition in schizophrenia using novel PET ligands related to AMPA
| Project/Area Number |
16K19790
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Kubota Manabu 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 脳機能イメージング研究部, 研究員(任常) (30760368)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | グルタミン酸 / 精神疾患 |
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| Outline of Final Research Achievements |
Although alterations in central glutamatergic neurotransmission are implicated in schizophrenia, in vivo visualization of glutamatergic neurotransmission is challenging. Using PET radioligands that we recently developed, we demonstrated possibilities to quantify status of glutamatergic neurotransmission including AMPA receptor in the living brain. Utilizing glutamate-PET as well as MRS, we investigated aberrant glutamatergic neurotransmission in patients with schizophrenia.
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| Academic Significance and Societal Importance of the Research Achievements |
脳内神経伝達機能は統合失調症をはじめとする多くの精神疾患において重要な役割をもつと考えられているが、生体内でその変化を捉える方法は限られている。我々は新しいPET撮像手法を用いてAMPA受容体をはじめとする脳内グルタミン酸神経伝達の変化を捉える方法を開発し、その技術を応用することにより、統合失調症の病態メカニズムを解明できる可能性を示した。今回の研究により、脳内グルタミン酸神経伝達異常を対象とした統合失調症の新たな治療法開発につながると期待される。
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Report
(4 results)
Research Products
(9 results)
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[Presentation] Alterations of central metabotropic glutamate receptor 5 binding and glutamate concentrations by food intake2018
Author(s)
Kubota M, Kimura Y, Ichise M, Seki C, Shimada H, Shinotoh H, Takahata K, Kitamura S, Moriguchi S, Ishii T, Tagai K, Takado Y, Sano H, Obata T, Tokunaga M, Maeda J, Zhang MR, Suhara T, Higuchi M
Organizer
The 31st CINP World Congress of Neuropsychopharmacology
Related Report
Int'l Joint Research
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[Presentation] Binding of a metabotropic glutamate receptor subtype 5 radioligand, (E)-[11C]ABP688, in human brains assessed by test-retest PET scans2017
Author(s)
Kubota M, Kimura Y, Ichise M, Seki C, Takahata K, Kitamura S, Moriguchi S, Ishii T, Zhang MR, Higuchi M, Suhara T
Organizer
28th Symposium on Cerebral Blood Flow, Metabolism and Function 13th Conference on Quantification of Brain Function with PET
Related Report
Int'l Joint Research
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[Presentation] Total and high-affinity-state dopamine D2 receptors in the striatum of antipsychotic-free patients with schizophrenia: a PET study with [11C]raclopride and [11C]MNPA2017
Author(s)
Kubota M, Nagashima T, Takano H, Kodaka F, Fujiwara H, Takahata K, Moriguchi S, Kimura Y, Higuchi M, Okubo Y, Takahashi H, Suhara T
Organizer
13th World Congress of Biological Psychiatry
Related Report
Int'l Joint Research
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