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覚醒療法のグルタミン酸神経伝達調節薬による抗うつ増強効果の検討

Research Project

Project/Area Number 16K19794
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionShiga University of Medical Science

Principal Investigator

吉池 卓也  滋賀医科大学, 医学部, 助教 (40647624)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Discontinued (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords覚醒療法 / グルタミン酸 / D-cycloserine / 双極性障害 / 神経可塑性 / 光療法 / 時間知覚 / 大うつ病性障害 / 時間生物学 / 睡眠医学 / 神経生理学 / 精神医学 / D-サイクロセリン / 精神生理学 / 精神薬理学 / 睡眠医科学 / 時間治療学
Outline of Annual Research Achievements

覚醒療法は、低用量ケタミンに次ぐ即時抗うつ効果のみならず、光療法や薬物療法の併用によりすぐれた維持効果を発揮する治療法であり、双極性障害及び大うつ病性障害の新たな治療戦略として海外では臨床的有用性が実証されている。他方、その作用機序については不明な点が多く、難治性病態の克服にも課題を残す。グルタミン酸神経伝達修飾は、ケタミンの作用機序と同様に覚醒療法に対する抗うつ反応においても重要な役割を担う可能性が示唆される。本研究課題は、覚醒依存的な神経可塑性に関連するグルタミン酸受容体部分アゴニストD-cycloserine(DCS)による覚醒療法の増強効果を検証することを目的とした。研究代表者の異動に続き、研究期間内に海外留学を開始することとなり、DCS併用療法の導入を見合わせ、光療法と併用した覚醒療法の臨床的有用性及びその治療メカニズムを検討する計画に変更した。少数例において本プロトコルの臨床的有用性が確認された。概日指標として治療中の時間知覚と治療効果の関連を検討したところ、時間知覚が気分と高い近縁性を有し、治療初期における時間知覚の概日変動が覚醒療法の治療効果を予測することが示唆された。研究代表者の海外留学の期間延長に伴い期間中の研究再開が困難となり、平成30年度に本研究は終了となった。

Report

(3 results)
  • 2018 Annual Research Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (26 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results) Presentation (21 results) (of which Int'l Joint Research: 10 results)

  • [Journal Article] Effects of bright light exposure on human fear conditioning, extinction, and associated prefrontal activation2018

    • Author(s)
      Yoshiike Takuya、Honma Motoyasu、Yamada Naoto、Kim Yoshiharu、Kuriyama Kenichi
    • Journal Title

      Physiology & Behavior

      Volume: 194 Pages: 268-276

    • DOI

      10.1016/j.physbeh.2018.06.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evidence for the Efficacy of Bright Light Therapy for Bipolar Depression2018

    • Author(s)
      Benedetti Francesco、Avery David H.、Bauer Michael、Bunney William E.、Caliyurt Okan、Camardese Giovanni、Colombo Cristina、Dallaspezia Sara、Henriksen Tone Elise、Kasper Siegfried、Kuriyama Kenichi、et al.
    • Journal Title

      American Journal of Psychiatry

      Volume: 175 Issue: 9 Pages: 905-906

    • DOI

      10.1176/appi.ajp.2018.18020231

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] COMT genotype is associated with plasticity in sense of body ownership:a pilot study2017

    • Author(s)
      Honma M, Yosiike T, Ikeda K, Kuriyama K
    • Journal Title

      Psychological Research

      Volume: in press Issue: 3 Pages: 634-644

    • DOI

      10.1007/s00426-017-0849-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Altered sleep spindle in delayed encephalopathy after acute carbon monoxide poisoning2016

    • Author(s)
      Yoshiike T, Nishida M, Yagishita K, Nariai T, Ishii K, Nishikawa T
    • Journal Title

      J Clin Sleep Med

      Volume: 12 Issue: 06 Pages: 913-915

    • DOI

      10.5664/jcsm.5900

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 睡眠薬の適正使用:依存・耐性2016

    • Author(s)
      吉池卓也,栗山健一
    • Journal Title

      CLINICIAN

      Volume: 8 Pages: 730-738

    • Related Report
      2016 Research-status Report
  • [Presentation] Sleep deprivation triggers shared temporal dynamics of time and mood perception in bipolar depression2018

    • Author(s)
      Yoshiike T, Dallaspezia S, Kuriyama K, Yamada N, Colombo C, Benedetti F
    • Organizer
      24th Congress of the European Sleep Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Electrophysiological correlates of antidepressant response to sleep deprivation: preliminary findings by using a 1-ch EEG device2018

    • Author(s)
      Yoshiike T, Suzuki M, Dallaspezia S, Kashiwagi K, Kuriyama K, Uchiyama M, Colombo C, Benedetti F
    • Organizer
      ECNS 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fluctuation of time perception correlates with antidepressant response to sleep deprivation in bipolar disorder2018

    • Author(s)
      Yoshiike T, Dallaspezia S, Rossi F, Kuriyama K, Yamada N, Colombo C, Benedetti F
    • Organizer
      日本睡眠学会第43回定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Shared temporal dynamics of time and mood perception in response to sleep deprivation in bipolar depression2018

    • Author(s)
      Yoshiike T, Dallaspezia S, Kuriyama K, Yamada N, Colombo C, Benedetti F
    • Organizer
      The 9th Congress of Asian Sleep Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bright light exposure triggers earlier onset of selective consolidation of motor-skill accuracy in humans2018

    • Author(s)
      Yoshiike T, Honma M, Yamada N, Kuriyama K
    • Organizer
      30th Annual Meeting of Society for Light Treatment & Biological Rhythms
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insomnia as a somatic representation of anxiety in the symptomatology of depression2017

    • Author(s)
      Yoshiike T, Kuriyama K, Nakasato Y, Yamada N, Nakamura M
    • Organizer
      World Sleep 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] A research project aimed at developing practical use of sleep EEG for diagnosis of major depressive disorder: multicenter exploratory prospective study2017

    • Author(s)
      Kuriyama K, Suzuki M, Kadotani H, Yoshinaka H, Yamanaka M, Omori T, Mori A, Tsuboi H, Ueda T, Kashiwagi K, Yoshimura A, Yoshiike T, Takahashi M, Matsuo M, Morita S, Takami M, Fujii Y, Nakabayashi T, Yamada N
    • Organizer
      World Sleep 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bright light enhances precocious expression of motor skill consolidation while optimizing speed-accuracy trade-off in humans2017

    • Author(s)
      Yoshiike T, Honma M, Kuriyama K
    • Organizer
      13th World Congress of Biological Psychiatry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The role for insomnia and somatic anxiety in the symptomatology and pharmacotherapy in remitted depression2017

    • Author(s)
      Yoshiike T, Nakasato Y, Kuriyama K, Nakamura M
    • Organizer
      13th World Congress of Biological Psychiatry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Grief shares circuits with pleasantness: subliminal grief priming activates the orbitofrontal cortex to boost empathic pain2017

    • Author(s)
      Yoshiike T, Kuriyama K, Ikeda H, Ohmura H, Honma M, Moriguchi Y, Asano K, Kim Y, Nakajima S
    • Organizer
      13th World Congress of Biological Psychiatry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The role for emotional memory consolidation in the pathophysiologies of anxiety and depression: a potential target for chronotherapeutics2016

    • Author(s)
      吉池卓也,栗山健一
    • Organizer
      第23回日本時間生物学会学術大会
    • Place of Presentation
      名古屋大学(名古屋)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Presentation] 複雑性悲嘆においてサブリミナル悲嘆刺激は共感性疼痛を促進する2016

    • Author(s)
      吉池卓也,中島聡美,本間元康,池田大樹,大村英史,淺野敬子,金吉晴,守口善也,栗山健一
    • Organizer
      第38回日本生物学的精神医学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] Sex difference in human fear conditioning and extinction associated with the COMT Val-Met polymorphism2016

    • Author(s)
      栗山健一,吉池卓也,金吉晴,山田尚登
    • Organizer
      第38回日本生物学的精神医学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Presentation] REM睡眠中の情動記憶強化過程2016

    • Author(s)
      吉池卓也
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル(新宿)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] うつ病における不眠と身体不安2016

    • Author(s)
      吉池卓也,中里容子,栗山健一,中村元昭
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル(新宿)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 高照度光による手続き記憶強化プロセスの検討2016

    • Author(s)
      吉池卓也,本間元康,池田大樹,栗山健一
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル(新宿)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 残遺不眠が職場復帰準備性に与える影響の検討2016

    • Author(s)
      吉池卓也,中里容子,福永薫子,我妻優,原澤祐子,中村元昭
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル(新宿)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠は平衡感覚機能の遅延学習を促進する2016

    • Author(s)
      本間元康,吉池卓也,池田大樹,栗山健一
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル(新宿)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 指示忘却と睡眠が恐怖記憶に及ほす神経学的メカニズムの検討2016

    • Author(s)
      池田大樹,吉池卓也,本間元康,大村英史,野添健太,栗山健一
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル(新宿)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Bright light enhances motor skill acquisition in humans2016

    • Author(s)
      Yoshiike T, Honma M, Kuriyama K
    • Organizer
      28th Annual Meeting of Society for Light Treatment & Biological Rhythms
    • Place of Presentation
      New York State Psychiatric Institute (NY, USA)
    • Year and Date
      2016-06-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 複雑性悲嘆における共感性に関連した病態特性2016

    • Author(s)
      吉池卓也,中島聡美,本間元康,池田大樹,大村英史,淺野敬子,金吉晴,守口善也,山田尚登, 栗山健一
    • Organizer
      第119回近畿精神神経学会学術集会
    • Place of Presentation
      京都市国際交流会館(京都)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-12-27  

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