| Project/Area Number |
16K19796
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center |
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Principal Investigator |
Kajitani Naoto 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 研究員(移行) (60755742)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | GDNF / 抗うつ薬 / うつ病 / アストロサイト / 精神神経薬理 |
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| Outline of Final Research Achievements |
In this study, I examined the hypothesis that glial cell line-derived neurotrophic factor (GDNF) in brain astrocytes plays a role as one of the molecular basis of refractory of major depressive disorder. In vitro study, I identified lysophosphatidic acid receptor 1 (LPA1) as an important receptor for the antidepressant-induced GDNF production in astrocytes. In vivo study, I revealed that chronic antidepressant treatment-induced behavioral effect was blocked by co-administration with LPA1 inhibitor and its effect was not observed in LPA1 hetero KO mice. I also found that expression of GDNF in the striatum and hippocampus might be important for the behavioral effect of antidepressant.
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