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The analyses of pathomechanisms of radiation-induced impairment in cognitive by using advanced MR imaging

Research Project

Project/Area Number 16K19802
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

LI LI  東北大学, 医学系研究科, 非常勤講師 (90769960)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords放射線治療 / 認知機能 / 脳微細構造 / Advanced MR imaging / 小児癌 / 遅発性認知機能障害 / 脳微細構造変化 / MR imaging / 小児がん / MRI / MRI / 小児 / がん / 高次機能障害
Outline of Final Research Achievements

As survival among children treated for cancer continues to improve, more attention is being focused on the late effects of cancer treatment. This study is an investigation of late neurocognitive sequelae in survivors of low grade brain tumors in childhood. We found that radiation field and radiation dose were associated with the number of microbleeds detected on T2*GRE MR imaging, and the subtle changes in tissue microstructure detected on neurite orientation dispersion and density imaging (NODDI), which might influence neurocognitive status in long-term survivors of these neoplasms. Our results help to inform the balance between risks and benefits that guide treatment decisions.

Academic Significance and Societal Importance of the Research Achievements

頭蓋内照射後の小児がん生存者の多くは小児がんが征圧されたにもかかわらず、学習障害、記憶障害、人付き合い困難、行動適応障害、長期にわたる教育・職業上の障害に苦悩している。本研究は脳微細構造変化の検出できるadvanced MR imagingを用いて放射線照射後遅発性認知機能障害の病態機構を解明し、将来生じうる認知機能障害を予測したMRI画像検査法を明らかにすることで、小児がん治療後に生じうる認知機能障害の早期発見、治療方針の決定に大きな影響を与えると思われる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] Perfusion contrast-enhanced ultrasound to predict early lymph-node metastasis in breast cancer.2019

    • Author(s)
      森菜緖子
    • Journal Title

      Japanese Journal of Radiology

      Volume: 37 Issue: 2 Pages: 145-153

    • DOI

      10.1007/s11604-018-0792-6

    • NAID

      210000170284

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative analysis of contrast-enhanced ultrasound imaging in invasive breast cancer: a novel technique to obtain histopathological information of microvessel density2017

    • Author(s)
      Mori N, Mugikura S, Takahashi S, Ito K, Takasawa C, Li L, Miyashita M, ko Kasajima A, Mori Y, Ishida T, Kodama T, Takase K
    • Journal Title

      Ultrasound Med Biol

      Volume: 43(3) Issue: 3 Pages: 607-614

    • DOI

      10.1016/j.ultrasmedbio.2016.11.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 転移性骨腫瘍にて発見され、画像上肝内に腫瘍を認めなかった肝細胞癌の1剖検例2019

    • Author(s)
      李麗
    • Organizer
      第216回 日本内科学会東北地方会
    • Related Report
      2018 Research-status Report
  • [Presentation] Morphologic features of intratumoral susceptibility signals on PRESTO for predicting the WHO grade of gliomas2016

    • Author(s)
      Li L, Mugikura S, Murata T, Akashi T, Sato S, Kanamori M, Watanabe M, Tamura H, Takahashi S, and Takase K.
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ (さいたま市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Comparative study of cerebral microvascular injury following whole-brain versus reduced-field irradiation in long-term survivors of intracranial germ cell tumors2016

    • Author(s)
      Li L, Mugikura S, Kumabe T, Murata T, Mori E, Takase K, Takahashi S, and Jingu K.
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Use of morphologic features of intratumoral susceptibility signals on PRESTO in predicting the preoperative grading of gliomas2016

    • Author(s)
      Li L, Mugikura S, Murata T, Akashi T, Sato S, Mata MD, Kanamori M, Watanabe M, Takahashi S, and Takase K.
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Traumatic Neuromaの1例2016

    • Author(s)
      李 麗
    • Organizer
      第8回脊椎・脊髄画像クラブ
    • Place of Presentation
      ベルサール東京日本橋 (東京都中央区)
    • Year and Date
      2016-04-02
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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