The establish of differential method between focal AIP and pancreas cancer based on the radiopathologic comparison.
| Project/Area Number |
16K19811
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
Inoue Dai 金沢大学, 附属病院, 助教 (00645129)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 自己免疫性膵炎 / 膵癌 / Focal AIP / CT / MRI / focal AIP / 放射線 / 病理学 |
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| Outline of Final Research Achievements |
Treatment for autoimmune pancreatitis differ from that for pancreas cancer.Though,the diagnosis of pancreas mass lesions largely depend on imaging examinations such as CT and MRI, imaging discrimination of mass forming autoimmune pancreatitis (focal AIP) and pancreas cancer remains challenging. Thus, in this study, we compared imaging features of focal AIP and pancreas cancer to reveal the imaging findings that can discriminate these two conditions.
We found that multiple dot-like enhancement, homogeneous enhancement and capsule-like rim were noted with high prevalence. Relying on these imaging findings, precise discrimination between focal AIP and pancreas cancer will be expected to be possible.
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| Academic Significance and Societal Importance of the Research Achievements |
。Focal AIPはステロイド内服で治療が可能であるにも関わらず、膵癌と鑑別が困難であるが故に、不必要な切除術が施行されてきた症例があり、また反対に膵癌にステロイド治療が施行され、適切な治療時期を逸してしまっている症例が少なからず存在していたが本研究により明らかにされた画像所見が広く認識されるようになるとCT, MRIといった低侵襲の画像検査で両者の鑑別が可能となり、膵腫瘤性病変を有する患者さんにとって大きなメリットとなる。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin and hepatocyte nuclear factor 4α in hepatocellular carcinoma.2018
Author(s)
Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Sato Y, Nakanuma Y, Harada K, Kita R, Gabata T.
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Journal Title
Hepatology Research
Volume: 48
Issue: 2
Pages: 205-216
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Imaging and pathological features of gastric lesion of immunoglobulin G4-related disease: A case report and review of the recent literature.2016
Author(s)
Inoue D, Yoneda N, Yoshida K, Nuka H, Kinoshita J, Fushida S, Toshima F, Minami T, Takahira M, Hamaoka S, Ikeda H, Gabata T, Kawano M.
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Journal Title
Mod Rheumatol.
Volume: 21
Pages: 1-5
Related Report
Peer Reviewed / Open Access
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[Journal Article] Factors related to renal cortical atrophy development after glucocorticoid therapy in IgG4-related kidney disease: a retrospective multicenter study.2016
Author(s)
Mizushima I, Yamamoto M, Inoue D, Nishi S, Taniguchi Y, Ubara Y, Matsui S, Yasuno T, Nakashima H, Takahashi H, Yamada K, Nomura H, Yamagishi M, Saito T, Kawano M.
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Journal Title
Arthritis Res Ther.
Volume: 25
Issue: 1
Pages: 273-273
DOI
NAID
Related Report
Peer Reviewed / Open Access
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