| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We demonstrated the applicability of photoacoustic (PA) imaging with indocyanine green (ICG) in a mouse tumor model. It allows safe and real-time imaging acquisition, and unlike common conventional contrast agents such as iodinated and gadolinium based contrast agents, ICG-enhanced PA imaging can less depict the IVC and hypervascular organs such as kidney and liver. The PA signal of ICG was rather enhanced in the interstitial extravascular space of tumors and salivary gland at the early phase after ICG injection. PA imaging with ICG allows for assessment of the early treatment response at a time when there is still no difference in tumor size after anti-VEGF therapy in this tumor model in mice and can directly reflect vascular permeability, which is not feasible at all with other imaging systems. Thus, PA imaging has a potential for the broader application for diagnosis of other pathologies characterized by changes in vascular permeability.
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