Development of novel PET probe to estimate protoporphyrin IX accumulation induced by 5-aminolevulinic acid

• Project/Area Number: 16K19815
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: SUZUKI Chie 浜松医科大学, 光尖端医学教育研究センター, 助教 (20637285)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: PET / アミノレブリン酸 / フッ素-18 / F-18 / 核医学

Outline of Final Research Achievements

We developed a novel 18F-labeled PET probe to estimate protoporphyrin IX accumulation induced by 5-aminolevulinic acid. Although the transport mechanism of the PET probe would be different from that of ALA, the PET probe could highly accumulate in a tumor, which show high accumulation of protoporphyrin IX induced by 5-aminolevulinic acid.

Academic Significance and Societal Importance of the Research Achievements

本研究の研究成果は、アミノレブリン酸 (ALA) 投与時の腫瘍におけるプロトポルフィリンIX (PpIX) 蓄積量を評価する臨床応用可能な画像診断法の可能性を示しており、本画像診断法が実現すれば、蛍光ガイド下摘出術の可否やPDTの治療効果といったがんの治療方針決定に有用な情報を与え、個々の患者に適した治療法を早期に選択することを可能とし、効率の良い治療へとつながり、年々増え続けるがん患者の予後改善に大きく貢献するものと期待される。