Establishment of high specific radioactivity 18F-FBPA new labeling synthesis method

• Project/Area Number: 16K19830
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyushu University
• Principal Investigator: Yamada Akifumi 九州大学, 大学病院, 学術研究員 (00565129)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: PET薬剤 / FBPA / PET / 放射性医薬品

Outline of Final Research Achievements

In this study, we tried to establish a new synthesis method of 18F-FBPA using 18F-, which gives higher radioactivity and specific radioactivity as compared with the conventional method using F2 gas.
We were able to obtain a new precursor of the purpose. However, labeling synthesis of 18F-FBPA could not be performed since the precursor was very unstable.