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Pathophysiological analysis of airway and obstructive diseases using 4D-dynamic ventilation CT

Research Project

Project/Area Number 16K19837
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Yamashiro Tsuneo  琉球大学, 医学(系)研究科(研究院), 講師 (30772545)

Research Collaborator MORIYA Hiroshi  大原綜合病院, 副院長
TSUKAGOSHI Shinsuke  キャノンメディカルシステムズ株式会社, CT開発部, 主任
KIMOTO Tatsuya  キャノンメディカルシステムズ株式会社, ヘルスケアICT開発センター, 主任
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
KeywordsCT / 慢性閉塞性肺疾患 / 中枢気道 / 呼吸運動 / 閉塞性換気障害 / COPD / 気管気管支軟化症 / 心不全 / 肺気腫 / 4次元CT / 気道 / 肺 / 放射線医学 / コンピュータ断層撮影
Outline of Final Research Achievements

Various pathophysiological findings were newly observed in COPD patients by the 4D-dynamic ventilation CT, which were summarized and published as multiple papers by international medical journals. They include 'paradoxical' respiratory movements of the proxial airways, asynchrony between lobar movements, and strange compression of the heart during expiration in COPD patients. I strongly believe that these new observations in COPD patients will make an influence on the future therapeutic strategies for COPD.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results)

  • [Journal Article] Preoperative assessment of pleural adhesion by Four-Dimensional Ultra-Low-Dose Computed Tomography (4D-ULDCT) with Adaptive Iterative Dose Reduction using Three-Dimensional processing (AIDR-3D)2018

    • Author(s)
      Hashimoto M, Nagatani Y, Oshio Y, Nitta N, Yamashiro T, Tsukagoshi S, Ushio N, Mayumi M, Kimoto T, Igarashi T, Yoshigoe M, Iwai K, Tanaka K, Sato S, Sonoda A, Otani H, Murata K, Hanaoka J
    • Journal Title

      Eur J Radiol

      Volume: 98 Pages: 79-186

    • DOI

      10.1016/j.ejrad.2017.11.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parietal pleural invasion/adhesion of subpleural lung cancer: Quantitative 4-dimensional CT analysis using dynamic-ventilatory scanning2017

    • Author(s)
      Sakuma K, Yamashiro T, Moriya H, Murayama S, Ito H
    • Journal Title

      Eur J Radiol

      Volume: 86 Pages: 36-44

    • DOI

      10.1016/j.ejrad.2016.12.004

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asynchrony in respiratory movements between the pulmonary lobes in patients with chronic obstructive pulmonary disease: Continuous measurement of lung density by 4-dimensional dynamic-ventilation CT2017

    • Author(s)
      Yamashiro T, Moriya H, Matsuoka S, Nagatani Y, Tsubakimoto M, Tsuchiya N, Murayama S
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 12 Pages: 2101-2109

    • DOI

      10.2147/copd.s140247

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperinflated lungs compress the heart during expiration in COPD patients: a new finding on dynamic-ventilation computed tomography2017

    • Author(s)
      Xu Y, Yamashiro T, Moriya H, Tsubakimoto M, Tsuchiya N, Nagatani Y, Matsuoka S, Murayama S
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 12 Pages: 3123-3131

    • DOI

      10.2147/copd.s145599

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous quantitative measurement of the proximal airway dimensions and lung density on four-dimensional dynamic-ventilation CT in smokers2016

    • Author(s)
      Tsuneo Yamashiro, Hiroshi Moriya, Maho Tsubakimoto, Shin Matsuoka, Sadayuki Murayama
    • Journal Title

      International Journal of Chronic Obstructtive Pulmonary Disease

      Volume: 11 Pages: 755-764

    • DOI

      10.2147/copd.s100658

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 胸部4DCT「呼吸ダイナミックCT」の臨床応用の可能性2016

    • Author(s)
      山城恒雄
    • Journal Title

      映像情報Medical

      Volume: 48 Pages: 120-124

    • Related Report
      2016 Research-status Report
  • [Presentation] 4-dimensional chest CT under free breathing: The advantages of dynamic-ventilation CT for novel thoracic imaging2018

    • Author(s)
      Yamashiro T
    • Organizer
      17th Asian-Oceanian Congress of Radiology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Continuous measurement of lung density by dynamic-ventilation CT: synchrony in respiratory movements in COPD patients and non-COPD smokers2017

    • Author(s)
      Yamashiro T, Moriya H, Tsubakimoto M, Tsuchiya N, Murayama S
    • Organizer
      8th International Workshop on Pulmonary Functional Imaging
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Asynchrony in respiratory movements between the pulmonary lobes of patients with COPD: Continuous measurement of lung density by dynamic-ventilation CT2017

    • Author(s)
      Yamashiro T, Moriya H, Tsubakimoto M, Tsuchiya N, Murayama S
    • Organizer
      113th International Conference of the American Thoracic Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Asynchrony of respiratory movement in COPD patients: Continuous measurement of lung density in five lung lobes on four-dimensional dynamic-ventilation CT2017

    • Author(s)
      Yamashiro T, Moriya H, Tsubakimoto M, Tsuchiya N, Murayama S
    • Organizer
      4th Meeting of the World Congress of Thoracic Imaging
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Preoperative assessment of parietal pleural invasion/adhesion of subpleural lung cancer: advantage of software-assisted analysis using 4-dimensional dynamic-ventilation CT2017

    • Author(s)
      Yamashiro T, Tsubakimoto M, Moriya H, Nagatani Y, Tsuchiya N, Murayama S
    • Organizer
      103rd Annual Meeting of the Radiological Society of North America
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胸部4D-CT「呼吸ダイナミックCT」2017

    • Author(s)
      山城恒雄
    • Organizer
      第9回呼吸機能イメージング研究会
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Invited
  • [Presentation] 呼吸ダイナミックCTを用いた喫煙者の連続的肺野濃度解析:左右の肺運動の同時性と閉塞性障害の関連2017

    • Author(s)
      山城恒雄、森谷浩史、椿本真穂、村山貞之
    • Organizer
      第9回呼吸機能イメージング研究会
    • Place of Presentation
      京都大学(京都府京都市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Continuous measurement of lung density by dynamic-ventilation CT: synchrony in respiratory movements in COPD patients and non-COPD smokers2017

    • Author(s)
      Tsuneo Yamashiro, Hiroshi Moriya, Maho Tsubakimoto, Nanae Tsuchiya, Sadayuki Murayama
    • Organizer
      8th International Workshop on Pulmonary Functional Imaging
    • Place of Presentation
      Seoul
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Four-dimensional chest CT with free breathing: the use of dynamic-ventilatory scanning for various thoracic diseases2016

    • Author(s)
      Tsuneo Yamashiro, Hiroshi Moriya, Yukihiro Nagatani, Osamu Honda, Atsuko Fujikawa, Sadayuki Murayama
    • Organizer
      102nd Annual Meeting of the Radiological Society of North America
    • Place of Presentation
      Chicago
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Continuous quantitative measurement of the proximal airway dimensions and lung density on 4-dimensional dynamic-ventilation CT in smokers2016

    • Author(s)
      Tsuneo Yamashiro, Hiroshi Moriya, Maho Tsubakimoto, Sadayuki Murayama
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Continuous measurement of lung density on dynamic-ventilation CT: disconnection in respiratory movement between the right and left lungs in patients with COPD2016

    • Author(s)
      Tsuneo Yamashiro, Hiroshi Moriya, Maho Tsubakimoto, Sadayuki Murayama
    • Organizer
      112th International Conference of the American Thoracic Society
    • Place of Presentation
      San Francisco
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肺容積で考える呼吸機能イメージング:2Dから4DCTへの道2016

    • Author(s)
      山城恒雄
    • Organizer
      第52回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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