Creation of appropriate contrast-weighting and analysis of brain diseases by synthetic and quantitative MRI
Project/Area Number |
16K19852
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Radiation science
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Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | MRI / Synthetic MRI / Quantitative MRI / 多発性硬化症 / Sturge-Weber症候群 / 視神経脊髄炎 / myelin imaging / deep learning / quantitative MRI / Brain Volumetry / 放射線 / 脳神経疾患 |
Outline of Final Research Achievements |
Synthetic MRI enables creation of any contrast-weighted image by post-processing based on a single quantitative MRI sequence for simultaneous quantification of T1 and T2 relaxation times and proton density. Myelin map can also be created based on these values. In this study, we established the reliability of the quantitative values acquired by synthetic MRI, which would be beneficial in multi-center study in the future. We also adjusted the contrast-weighted images created by synthetic MRI and applied them to diseases such as multiple sclerosis (MS) and brain metastases for detecting focal lesions. Further, we detected white matter damage in patients with MS by quantitative MR values, and showed that myelin map was more sensitive to the disease process of MS than T1, T2, and proton density. Myelin map could be a clinical biomarker of MS clinical practice in the future.
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Academic Significance and Societal Importance of the Research Achievements |
Synthetic MRIで得られる各種定量値を3つの異なる会社のMRI機器にて包括的に評価し、Synthetic MRIによる多施設共同研究への道が開かれた。Synthetic MRIのミエリン量マップが時間のかかる従来法と白質においてよく相関することを示し、また、ミエリン量マップが従来法MRIでは検出できないMSの白質障害・灰白質障害を検出し、いずれに対しても他のMRI定量値より感度の高いバイオマーカーであることを示した。臨床応用への道が開かれたと考えられる。多発性硬化症プラーク検出におけるSynthetic MRIの適切なコントラストも見出した。
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Effect of Gadolinium on the Estimation of Myelin and Brain Tissue Volumes Based on Quantitative Synthetic MRI.2019
Author(s)
Maekawa T, Hagiwara A, Hori M, Andica C, Haruyama T, Kuramochi M, Nakazawa M, Koshino S, Irie R, Kamagata K, Wada A, Abe O, Aoki S.
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Journal Title
Am J Neuroradiol.
Volume: 40
Issue: 2
Pages: 231-237
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods.2018
Author(s)
Hagiwara A, Hori M, Kamagata K, Warntjes M, Matsuyoshi D, Nakazawa M, Ueda R, Andica C, Koshino S, Maekawa T, Irie R, Takamura T, Kumamaru KK, Abe O, Aoki S
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 10554-10554
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio.2018
Author(s)
Hagiwara A, Hori M, Yokoyama K, Nakazawa M, Ueda R, Horita M, Andica C, Abe O, Aoki S.
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Journal Title
AJNR Am J Neuroradiol
Volume: 38
Issue: 10
Pages: 1934-1940
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Advantage of Synthetic MRI for the Visualization of Anterior Temporal Pole Lesions on Double Inversion Recovery (DIR), Phase-sensitive Inversion Recovery (PSIR), and Myelin Images in a Patient with CADASIL2018
Author(s)
Wallaert L, Hagiwara A, Andica C, Hori M, Yamashiro K, Koshino S, Maekawa T, Kamagata K, Aoki S.
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 17
Issue: 4
Pages: 275-276
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Utility of a Multiparametric Quantitative MRI Model That Assesses Myelin and Edema for Evaluating Plaques, Periplaque White Matter, and Normal-Appearing White Matter in Patients with Multiple Sclerosis: A Feasibility Study.2017
Author(s)
Hagiwara A, Hori M, Yokoyama K, Takemura MY, Andica C, Kumamaru KK, Nakazawa M, Takano N, Kawasaki H, Sato S, Hamasaki N, Kunimatsu A, Aoki S
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Journal Title
AJNR Am J Neuroradiol
Volume: 38
Issue: 2
Pages: 237-242
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Synthetic MRI in the Detection of Multiple Sclerosis Plaques.2017
Author(s)
Hagiwara A, Hori M, Yokoyama K, Takemura MY, Andica C, Tabata T, Kamagata K, Suzuki M, Kumamaru KK, Nakazawa M, Takano N, Kawasaki H, Hamasaki N, Kunimatsu A, Aoki S.
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Journal Title
AJNR Am J Neuroradiol
Volume: 38
Issue: 2
Pages: 257-263
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] SyMRI of the Brain: Rapid Quantification of Relaxation Rates and Proton Density, With Synthetic MRI, Automatic Brain Segmentation, and Myelin Measurement.2017
Author(s)
Hagiwara A, Warntjes M, Hori M, Andica C, Nakazawa M, Kumamaru KK, Abe O, Aoki S
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Journal Title
Invest Radiol
Volume: 印刷中
Issue: 2
Pages: 178-186
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The Advantage of Synthetic MRI for the Visualization of Early White Matter Change in an Infant with Sturge-Weber Syndrome2016
Author(s)
Andica C, Hagiwara A, Nakazawa M, Tsuruta K, Takano N, Hori M, Suzuki H, Sugano H, Arai H, Aoki S
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 15
Issue: 4
Pages: 347-348
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access
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[Presentation] Conditional Generative Adversarial Network(cGAN)を使用した深層学習によるSynthetic FLAIRの画質向上2018
Author(s)
Akifumi Hagiwara, Yujiro Otsuka, Masaaki Hori, Shohei Fujita, Koji Kamagata, Ryusuke Irie, Tomoko Maekawa, Christina Andica, Akihiko Wada, Moeko Horita, Takuya Haruyama, Osamu Abe, Shigeki Aoki
Organizer
第46回日本磁気共鳴医学会大会
Related Report
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[Presentation] Rapid Myelin Measurement: Comparison Between SyMRI (Simultaneous Tissue Relaxometry), Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods2018
Author(s)
Akifumi Hagiwara, Masaaki Hori, Koji Kamagata, Misaki Nakazawa, Christina Andica, Tomoko Maekawa, Saori Koshino, Ryusuke Irie, Lydia Chougar, Osamu Abe, Shigeki Aoki
Organizer
26th ISMRM International Society for Magnetic Resonance in Medicine
Related Report
Int'l Joint Research
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