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Assessment of brain change by aging and neurodegeneration using transparent brain and diffusion MRI: 3 dimensional comparison of imaging with pathology

Research Project

Project/Area Number 16K19853
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionJuntendo University

Principal Investigator

Sato Kanako  順天堂大学, 医学部, 助教 (80755520)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords拡散MRI / NODDI / 透明脳 / 脳微細構造 / 加齢 / 変性 / DTI / DKI / 脊髄小脳変性症 / TBSS / マウス脳
Outline of Final Research Achievements

To understand change of microstructure and neural networks in the brain by aging, we performed basic research using mouse brain.
We compared imaging findings and pathological findings of normal mouse brain. A new method of diffusion MRI and a histological method to render the mouse brain transparent were used for analysis. Neurite density and degree of orientation dispersion of nerve fibers were compared between areas containing crossing fibers (crossing areas) and parallel fibers (parallel areas) in the anterior commissure and the hippocampus. Degree of orientation dispersion of nerve fibers was consistent with pathological findings. The results validated that this new diffusion MRI method has potential to assess microstructural change of the brain by aging at pathological level.

Academic Significance and Societal Importance of the Research Achievements

難病といわれる種々の神経変性疾患の予後を改善するためには、画像による早期診断と正確な評価が重要な役割を果たす。そのためには、病理所見に対応した脳微細構造の評価が可能な画像診断法の開発が望まれている。
この研究では、最新の拡散MRIにより正常加齢による脳微細構造と脳内神経ネットワークの変化が解明可能であることが示され、神経変性疾患の脳内構造と比較するベースラインを確立する一歩となった。このような画像と病理の対比研究の蓄積により、将来的には、MRIにより生体の全脳を細胞レベルで評価し、疾患の病態解明や治療方針の決定に活用できる可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Int'l Joint Research] GHU-Paris Sainte-Anne/Paris Descartes Sorbonne University/Inst. of Psychiatry and Neurosciences(フランス)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Atlas of IDH Wild-Type Supratentorial Glioblastoma: Probabilistic Maps of Phenotype, Management, and Outcomes.2019

    • Author(s)
      Roux A, Roca P, Edjlali M, K Sato, Zanello M, Dezamis E, Gori P, Lion S, Fleury A, Dhermain F, Meder JF, Chrétien F, Lechapt E, Varlet P, Oppenheim C, Pallud J.
    • Journal Title

      Radiology

      Volume: 293 Issue: 3 Pages: 633-643

    • DOI

      10.1148/radiol.2019190491

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain.2017

    • Author(s)
      Sato K, Kerever A, Kamagata K, Tsuruta K, Irie R, Tagawa K, Okazawa H, Arikawa-Hirasawa E, Nitta N, Aoki I, Aoki S.
    • Journal Title

      Acta Radiologica Open

      Volume: 6 Issue: 4 Pages: 1-6

    • DOI

      10.1177/2058460117703816

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ディープラーニングによる乳幼児脳MRIにおける髄鞘化程度推定の試み2019

    • Author(s)
      和田昭彦、齋藤勇哉、入江隆介、藤田翔平、鎌形康司、前川朋子、佐藤香菜子、鈴木通真、堀正明、青木茂樹
    • Organizer
      第48回日本神経放射線学会,久留米,2019.2.14-16
    • Related Report
      2019 Annual Research Report
  • [Presentation] JF Meder. Bottom of sulcus dysplasia (BOSD): why they should be recognized?2019

    • Author(s)
      K Sato, C. Mellerio, F Chassoux, B Devaux, C. Oppenheim
    • Organizer
      Journees Francophones de Radiologie (JFR), Paris, France, October.11-14 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Advanced diffusion MR imaging (NODDI) : comparison with a transparent mouse brain2016

    • Author(s)
      Sato K, Kerever A, Kamagata K, Aoki S.
    • Organizer
      Organization of Human brain Mapping
    • Place of Presentation
      ジュネーブ
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 「てんかんの画像診断」 日本医師会雑誌特集 てんかん診療の最前線2019

    • Author(s)
      明石敏昭、佐藤香菜子、青木茂樹.
    • Total Pages
      3
    • Publisher
      日本医師会
    • Related Report
      2019 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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