Elucidation of pathophysiology of Parkinson's disease by neurite orientation dispersion and density imaging

• Project/Area Number: 16K19854
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Juntendo University
• Principal Investigator: Kamagata Koji 順天堂大学, 医学部, 准教授 (60568153)
• Research Collaborator: HORI masaaki ; ANDICA christina
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: パーキンソン病 / 拡散MRI / 神経突起イメージング / 灰白質 / 白質 / コネクトーム / 大脳灰白質 / 黒質線条体 / 皮質基底核ネットワーク / 黒質線条体路 / MRI

Outline of Final Research Achievements

In this research, we demonstrated the ability of neurite orientation dispersion and density imaging (NODDI) in the in vivo evaluation of the brain in patients with Parkinson's disease (PD). NODDI was able to detect cerebral grey matter degeneration in PD patients, and NODDI parameters of grey matter were also well correlated with motor symptoms score of PD. We also reported that NODDI was able to show the degeneration of nigrostriatal pathways, which is the main cause of PD motor symptoms. In another study, we reported that disruption of cortico-basal ganglia-thalamocortical networks in PD could be detected more sensitively using diffusion-weighted MRI tractography and a multi-shell, multi-tissue (MSMT) constrained spherical deconvolution (CSD) method compared to conventional CSD method. From our research results, NODDI and MSMT-CSD methods are considered to be useful for evaluation of microstructural and neural networks changes of PD’s brain.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果により、拡散MRIによる神経突起イメージングがパーキンソン病患者の脳内に起きている病的な変化を患者が生存している状態で検出することが可能であることが示唆された。今後、神経突起イメージングがパーキンソン病患者の治療に対する反応性の評価や早期診断に有用であることが確立されれば、パーキンソン病の新たな治療薬の薬効評価や早期治療の開始に有用であることが期待される。

Research Products

• [Int'l Joint Research] Melbourne Neuropsychiatry Centre(オーストラリア)
• [Int'l Joint Research] The University of Melbourne(Australia)
• [Journal Article] Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson's disease: Retrograde degeneration observed by tract-profile analysis. (2018)
  • Author(s): Andica C, Kamagata K, Hatano T, Okuzumi A, Saito A, Nakazawa M, Ueda R, Motoi Y, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
  • Journal Title: Parkinsonism & Related Disorders Volume: 18 Pages: 30112-30113
  • DOI: 10.1016/j.parkreldis.2018.02.046
  • Peer Reviewed / Open Access
• [Journal Article] Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution. (2017)
  • Author(s): Kamagata K, Zalesky A, Hatano T, Di Biase MA, El Samad O, Saiki S, Shimoji K, Kumamaru KK, Kamiya K, Hori M, Hattori N, Aoki S, Pantelis C.
  • Journal Title: Neuroimage Clinical Volume: 17 Pages: 518-529
  • DOI: 10.1016/j.nicl.2017.11.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging. (2017)
  • Author(s): Kamagata K, Zalesky A, Hatano T, Ueda R, Di Biase MA, Okuzumi A, Shimoji K, Hori M, Caeyenberghs K, Pantelis C, Hattori N, Aoki S.
  • Journal Title: Human Brain Mapping Volume: in press Issue: 7 Pages: 3704-3722
  • DOI: 10.1002/hbm.23628
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 深層学習を用いた脳幹構造による進行性核上性麻痺とパーキンソン病の鑑別 (2019)
  • Author(s): 鎌形康司、 吉岡直紀、 波田野琢、内田航、Christina Andica、大山彦光、下泰司、梅村敦、堀正明、服部信孝、青木茂樹
  • Organizer: 第48回神経放射線学会
• [Presentation] Deep Learning with Convolutional Networks for Segmentation of substantia nigra on Neuromelanin MRI (2019)
  • Author(s): 鎌形康司、 大塚裕次郎、 波田野琢、倉持麻奈、Christina Andica、大山彦光、下泰司、梅村敦、堀正明、服部信孝、青木茂樹
  • Organizer: 第48回神経放射線学会
• [Presentation] FOD clusteringとNODDI profile解析を用いたパーキンソン病における帯状束変性の評価 (2018)
  • Author(s): Kamagata K, Okuhata S, Hatano T, Ida K, Ogawa T, Takashige H, Oyama G, Shimo Y, Andica C, Hori M, Kobayashi T, Hattori N, Aoki S.
  • Organizer: 第46回日本磁気共鳴医学会大会
• [Presentation] 神経認知精神障害を有するパーキンソン病患者における白質微細構造変性の評価 (2018)
  • Author(s): Christina Andica, Koji Kamagata, Taku Hatano, Asami Saito, Yuki Takenaka, Akifumi Hagiwara, Takashi Ogawa, Genko Oyama, Yasushi Shimo, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki
  • Organizer: 第46回日本磁気共鳴医学会大会
• [Presentation] Nigrosome-1の視覚化と神経メラニンイメージング (2018)
  • Author(s): 鎌形康司
  • Organizer: 第17回TNR倶楽部
  • Invited
• [Presentation] Connectome Analysis (2018)
  • Author(s): 鎌形康司
  • Organizer: 第 58 回日本核医学会学術総会シンポジウム8
  • Invited
• [Presentation] 新たな拡散MRIのポテンシャル (2018)
  • Author(s): 鎌形康司
  • Organizer: 第42回日本脳神経CI学会シンポジウム 2:神経放射線最先端診断技術
  • Invited
• [Presentation] MRI における脳機能イメージの進歩：脳神経回路網の側面から」 (2017)
  • Author(s): 鎌形康司
  • Organizer: 第33回Brain function imaging conference
  • Invited
• [Presentation] 拡散MRIの新しいポテンシャル：コネクトーム応用を中心に (2017)
  • Author(s): 鎌形康司
  • Organizer: 第45回日本磁気共鳴医学会大会
  • Invited
• [Presentation] Diffusion MRI in Parkinson's disease (2017)
  • Author(s): 鎌形康司
  • Organizer: AIMS Neuro Imaging 2017
  • Invited
• [Presentation] Advances in MRI biomarkers for diagnosing dementia (2016)
  • Author(s): 鎌形 康司
  • Organizer: 第52回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2016-09-16
  • Invited
• [Presentation] Neurite Orientation Dispersion and Density Imaging (NODDI) of Nigrostriatal Pathway in Parkinson Disease (2016)
  • Author(s): Misaki Nakazawa, Christina Andica, Koji Kamagata, Ryo Ueda, Sho Murata, Taku Hatano, Ayami Okuzumi, Osamu Abe, Michimasa Suzuki, Masaaki Hori, Kanako Kumamaru, Nobutaka Hattori, Shigeki Aoki
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 埼玉
  • Year and Date: 2016-09-09
• [Presentation] Evaluation of gray matter degeneration in Parkinson’s disease by using neuriteorientation dispersion and density imaging: Analysis by gray matter-based spatial statistics (2016)
  • Author(s): Koji Kamagata, Kouhei Tsuruta, Taku Hatano, Keigo Shimoji, Masaaki Hori, Ayami Okuzumi, Misaki Nakazawa, Syo Murata, Ryo Ueda, and Shigeki Aoki
  • Organizer: ISMRM 24rd Annual Meeting & Exhibition
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Book] Annual Review神経 パーキンソン病とMRI (2016)
  • Author(s): 鎌形 康司, 波田野 琢, 青木 茂樹
  • Total Pages: 9
  • Publisher: 中外医薬社