• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of pathophysiology of Parkinson's disease by neurite orientation dispersion and density imaging

Research Project

Project/Area Number 16K19854
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionJuntendo University

Principal Investigator

Kamagata Koji  順天堂大学, 医学部, 准教授 (60568153)

Research Collaborator HORI masaaki  
ANDICA christina  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsパーキンソン病 / 拡散MRI / 神経突起イメージング / 灰白質 / 白質 / コネクトーム / 大脳灰白質 / 黒質線条体 / 皮質基底核ネットワーク / 黒質線条体路 / MRI
Outline of Final Research Achievements

In this research, we demonstrated the ability of neurite orientation dispersion and density imaging (NODDI) in the in vivo evaluation of the brain in patients with Parkinson's disease (PD). NODDI was able to detect cerebral grey matter degeneration in PD patients, and NODDI parameters of grey matter were also well correlated with motor symptoms score of PD. We also reported that NODDI was able to show the degeneration of nigrostriatal pathways, which is the main cause of PD motor symptoms. In another study, we reported that disruption of cortico-basal ganglia-thalamocortical networks in PD could be detected more sensitively using diffusion-weighted MRI tractography and a multi-shell, multi-tissue (MSMT) constrained spherical deconvolution (CSD) method compared to conventional CSD method. From our research results, NODDI and MSMT-CSD methods are considered to be useful for evaluation of microstructural and neural networks changes of PD’s brain.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果により、拡散MRIによる神経突起イメージングがパーキンソン病患者の脳内に起きている病的な変化を患者が生存している状態で検出することが可能であることが示唆された。今後、神経突起イメージングがパーキンソン病患者の治療に対する反応性の評価や早期診断に有用であることが確立されれば、パーキンソン病の新たな治療薬の薬効評価や早期治療の開始に有用であることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 7 results) Book (1 results)

  • [Int'l Joint Research] Melbourne Neuropsychiatry Centre(オーストラリア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] The University of Melbourne(Australia)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson's disease: Retrograde degeneration observed by tract-profile analysis.2018

    • Author(s)
      Andica C, Kamagata K, Hatano T, Okuzumi A, Saito A, Nakazawa M, Ueda R, Motoi Y, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S.
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 18 Pages: 30112-30113

    • DOI

      10.1016/j.parkreldis.2018.02.046

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution.2017

    • Author(s)
      Kamagata K, Zalesky A, Hatano T, Di Biase MA, El Samad O, Saiki S, Shimoji K, Kumamaru KK, Kamiya K, Hori M, Hattori N, Aoki S, Pantelis C.
    • Journal Title

      Neuroimage Clinical

      Volume: 17 Pages: 518-529

    • DOI

      10.1016/j.nicl.2017.11.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging.2017

    • Author(s)
      Kamagata K, Zalesky A, Hatano T, Ueda R, Di Biase MA, Okuzumi A, Shimoji K, Hori M, Caeyenberghs K, Pantelis C, Hattori N, Aoki S.
    • Journal Title

      Human Brain Mapping

      Volume: in press Issue: 7 Pages: 3704-3722

    • DOI

      10.1002/hbm.23628

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 深層学習を用いた脳幹構造による進行性核上性麻痺とパーキンソン病の鑑別2019

    • Author(s)
      鎌形康司、 吉岡直紀、 波田野琢、内田航、Christina Andica、大山彦光、下泰司、梅村敦、堀正明、服部信孝、青木茂樹
    • Organizer
      第48回神経放射線学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Deep Learning with Convolutional Networks for Segmentation of substantia nigra on Neuromelanin MRI2019

    • Author(s)
      鎌形康司、 大塚裕次郎、 波田野琢、倉持麻奈、Christina Andica、大山彦光、下泰司、梅村敦、堀正明、服部信孝、青木茂樹
    • Organizer
      第48回神経放射線学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] FOD clusteringとNODDI profile解析を用いたパーキンソン病における帯状束変性の評価2018

    • Author(s)
      Kamagata K, Okuhata S, Hatano T, Ida K, Ogawa T, Takashige H, Oyama G, Shimo Y, Andica C, Hori M, Kobayashi T, Hattori N, Aoki S.
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 神経認知精神障害を有するパーキンソン病患者における白質微細構造変性の評価2018

    • Author(s)
      Christina Andica, Koji Kamagata, Taku Hatano, Asami Saito, Yuki Takenaka, Akifumi Hagiwara, Takashi Ogawa, Genko Oyama, Yasushi Shimo, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Nigrosome-1の視覚化と神経メラニンイメージング2018

    • Author(s)
      鎌形康司
    • Organizer
      第17回TNR倶楽部
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Connectome Analysis2018

    • Author(s)
      鎌形康司
    • Organizer
      第 58 回日本核医学会学術総会シンポジウム8
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 新たな拡散MRIのポテンシャル2018

    • Author(s)
      鎌形康司
    • Organizer
      第42回日本脳神経CI学会シンポジウム 2:神経放射線最先端診断技術
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MRI における脳機能イメージの進歩:脳神経回路網の側面から」2017

    • Author(s)
      鎌形康司
    • Organizer
      第33回Brain function imaging conference
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 拡散MRIの新しいポテンシャル:コネクトーム応用を中心に2017

    • Author(s)
      鎌形康司
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Diffusion MRI in Parkinson's disease2017

    • Author(s)
      鎌形康司
    • Organizer
      AIMS Neuro Imaging 2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Advances in MRI biomarkers for diagnosing dementia2016

    • Author(s)
      鎌形 康司
    • Organizer
      第52回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Neurite Orientation Dispersion and Density Imaging (NODDI) of Nigrostriatal Pathway in Parkinson Disease2016

    • Author(s)
      Misaki Nakazawa, Christina Andica, Koji Kamagata, Ryo Ueda, Sho Murata, Taku Hatano, Ayami Okuzumi, Osamu Abe, Michimasa Suzuki, Masaaki Hori, Kanako Kumamaru, Nobutaka Hattori, Shigeki Aoki
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      埼玉
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of gray matter degeneration in Parkinson’s disease by using neuriteorientation dispersion and density imaging: Analysis by gray matter-based spatial statistics2016

    • Author(s)
      Koji Kamagata, Kouhei Tsuruta, Taku Hatano, Keigo Shimoji, Masaaki Hori, Ayami Okuzumi, Misaki Nakazawa, Syo Murata, Ryo Ueda, and Shigeki Aoki
    • Organizer
      ISMRM 24rd Annual Meeting & Exhibition
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] Annual Review神経 パーキンソン病とMRI2016

    • Author(s)
      鎌形 康司, 波田野 琢, 青木 茂樹
    • Total Pages
      9
    • Publisher
      中外医薬社
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi