| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Using the measurement of unrepairable DNA double strand breaks(DNA-DSBs) as a indicator, we examined how inhibition of potentially lethal damage recovery(PLDR) affects the production of unrepairable DNA-DSBs by radiation. The inhibition of PLDR increased the number of unrepairable DNA-DSB. But there was no significant difference in the number of DSBs immediately after irradiation. We next tested whether histone demethylation inhibitors enhance the antitumor effects of radiation and anticancer agents in human prostate cancer and oral cancer cell lines. In both cell lines, the treatment with a histone demethylation inhibitor inhibited cell growth in a dose dependent manner. Furthermore, it was suggested that JIB-04 enhances the antitumor effect of radiation and is associated with DNA repair in prostate cancer.
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