MR imaging to predict early treatment response

• Project/Area Number: 16K19879
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: MURATA Shinichi 愛知県がんセンター(研究所), 分子腫瘍学分野, 研究員 (00748866)
• Research Collaborator: MATSUSHIMA Shigeru ; INABA Yoshitaka ; SATO Yozo
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 癌 / 磁化移動効果 / 早期治療効果判定 / 細胞密度画像 / 磁気共鳴 / 核磁気共鳴画像

Outline of Final Research Achievements

The purpose of this work is to perform the reactant early evaluation in liver tumor. Relative tumor enhancement (RTE) value could be a potential biomarker to predict early treatment response. It was difficult to detect correlation between equivalent cross-relaxation rate imaging (ECRI) and interventional treatment.

Academic Significance and Societal Importance of the Research Achievements

転移性肝腫瘍へのEOB造影率がRECIST criteriaに基づいた治療効果予測に有用であることが示唆された。ECRIを用いた検討から有意な結果が得られなかった理由は症例数と症例間のばらつきが大きかったことが考えられたため、今後の検討課題としたい。
本研究は化学療法への反応性を予測することで、肝切除術が施行できる症例を予知できる可能性を示唆した。

Research Products

• [Journal Article] The Utility of lndigo Carmine and Lipiodol Mixture for Preoperative Pulmonary Nodule Localization before Video-Assisted Thoracic Surgery (2019)
  • Author(s): Hasegawa T, Kuroda H, Sato Y, Matsuo K, Sakata S, Yashiro H, Sakakura N, Mizuno T, Arimura T, Yamaura H, Murata S, Imai Y, Sakao Y, Inaba Y
  • Journal Title: J Vasc Interv Radio Volume: 30 Issue: 3 Pages: 446-452
  • DOI: 10.1016/j.jvir.2018.08.024
  • Peer Reviewed
• [Journal Article] Covered stent placement for emergency repair of a ruptured superior mesenteric artery pseudoaneurysm in advanced pancreatic head cancer. (2019)
  • Author(s): Kimbara Y, Sato Y, Hasegawa T, Morinaga H, Murata S, Imai Y, Hara K, Okuno N, Inaba Y
  • Journal Title: Radiology Case Reorts 14, 133-135, 2019 Volume: 14 Issue: 1 Pages: 133-135
  • DOI: 10.1016/j.radcr.2018.10.012
• [Journal Article] Predicting chemotherapeutic response for colorectal liver metastases using relative tumor enhancement of gadoxetic acid disodium-enhanced magnetic resonance imaging (2018)
  • Author(s): Murata Shinichi、Matsushima Shigeru、Sato Yozo、Yamaura Hidekazu、Kato Mina、Hasegawa Takaaki、Muro Kei、Inaba Yoshitaka
  • Journal Title: Abdominal Radiology Volume: 43 Issue: 12 Pages: 3301-3306
  • DOI: 10.1007/s00261-018-1615-z
  • Peer Reviewed
• [Journal Article] Pathologic Diagnosis and Genetic Analysis of a Lung Tumor Needle Biopsy Specimen Obtained Immediately After Radiofrequency Ablation (2017)
  • Author(s): Hasegawa Takaaki、Kondo Chiaki、Sato Yozo、Inaba Yoshitaka、Yamaura Hidekazu、Kato Mina、Murata Shinichi、Onoda Yui、Kuroda Hiroaki、Sakao Yukinori、Yatabe Yasushi
  • Journal Title: CardioVascular and Interventional Radiology Volume: 41 Issue: 4 Pages: 594-602
  • DOI: 10.1007/s00270-017-1845-4
  • Peer Reviewed
• [Journal Article] Intrahepatic portosystemic venous shunt via the right adrenal vein:treatment with vascular plug. (2017)
  • Author(s): Murata S, Sato Y, Inaba Y, Yamaura H, Kato M, Kawada H, Hasegawa T, Asai T, Aramaki T
  • Journal Title: Minimally Invasive Therapy & Allied Technologies Volume: 26 Issue: 1 Pages: 51-55
  • DOI: 10.1080/13645706.2016.1216863
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Equivalent cross-relaxation rate imaging and diffusion weighted imaging for early prediction of response to bevacizumab-containing treatment in colorectal liver metastases - Preliminary Study. (2016)
  • Author(s): Matsushima S, Sato T, Nishiofuku H, Sato Y, Murata S, Kinosada Y, Era S, Inaba Y.
  • Journal Title: Clinical Imaging Volume: 41 Pages: 1-6
  • DOI: 10.1016/j.clinimag.2016.08.013
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] The relative tumor enhancement based on tumor heterogeneity for prediction of response to bevacizumab-containing treatment in liver metastases of colorectal cancer. (2019)
  • Author(s): Matsushima S, Murata S, Sato Y, Onaya H, Yamaura H, Kato M, Hasegawa T, Kinosada Y, Inaba Y
  • Organizer: European Congress of Radiology 2019
  • Int'l Joint Research
• [Presentation] EOB-MRIを用いた大腸癌肝転移に対する初期治療効果予測． (2018)
  • Author(s): 村田慎一，松島秀，佐藤洋造，山浦秀和，加藤弥菜，長谷川貴章，稲葉吉隆
  • Organizer: 第54回日本肝癌研究会
• [Presentation] Embolization for tumor of the innominate artery area. (2016)
  • Author(s): Murata S, Inaba Y, Sato Y, Kimbara Y, Morinaga H.
  • Organizer: Global Embolization Symposium and Technologies-GEST Asia 2016
  • Place of Presentation: 東京マリオット、東京
  • Year and Date: 2016-12-16
  • Int'l Joint Research