| Project/Area Number |
16K19889
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
TANAKA Yuri 名古屋大学, 医学部附属病院, 医員 (40772075)
|
|---|
| Research Collaborator |
KANDA Mitsuro 名古屋大学, 医学部附属病院, 助教 (00644668)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 胃癌 / 肝転移 / 分子標的 / バイオマーカー |
|---|
| Outline of Final Research Achievements |
Liver metastasis remains a serious problem in the management of gastric cancer (GC). Transcriptome data identified the overexpression of synaptotagmin VII (SYT7) in GC tissues with hepatic metastasis. SYT7 knockout inhibited the proliferation of GC cells and attenuated cell migration, invasion, and adhesion. The tumorigenicity of SYT7 knockout cells was moderately reduced in a mouse model of subcutaneous metastasis and was more strikingly attenuated in a model of hepatic metastasis. The SYT7 levels in the primary GC tissues were significantly associated with hepatic recurrence, metastasis, and adverse prognosis. SYT7 represents a tool for prediction and monitoring of hepatic metastasis from GC as well as being a promising therapeutic target.
|
