The preservation of the marginal graft using hydrogen super rich saline

• Project/Area Number: 16K19891
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Kyoto University
• Principal Investigator: OGAWA ERI 京都大学, 医学研究科, 特定助教 (30440506)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 虚血再灌流障害 / 肝移植後の肝癌再発 / 肝境界グラフト / 水素含有臓器保存液 / ラット同所性全肝移植 / 肝移植後肝癌再発 / 水素 / 虚血再灌流 / 臓器保存 / 境界グラフト

Outline of Final Research Achievements

Our basic data has not shown that the effect of hydrogen super rich saline in our hepatic pedicle clamping-induced ischemic reperfusion injury. We established orthotopic liver transplantation model in rat. All the grafted rats have survived for more than one hundred days. We have tried to make recurrence model for the rat liver transplantation for hepatocellular carcinoma. We have planned to verify the reduction effect of ischemic reperfusion injury by hydrogen super rich saline on the marginal graft model such as small-for-size graft and fatty liver transplantation model in addition to this model.

Research Products

• [Journal Article] 【胆道閉鎖症アップデート】 移植のタイミングと肝移植待機の問題点 (2018)
  • Author(s): 岡本晋弥
  • Journal Title: 小児外科 Volume: 50 Pages: 81-84
  • Int'l Joint Research
• [Journal Article] Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single-institute experience (2018)
  • Author(s): Umeda Katsutsugu、Okajima Hideaki、Kawaguchi Koji、Nodomi Seishiro、Saida Satoshi、Kato Itaru、Hiramatsu Hidefumi、Ogawa Eri、Yoshizawa Atsushi、Okamoto Shinya、Uemoto Shinji、Watanabe Kenichiro、Adachi Souichi
  • Journal Title: Pediatric Transplantation Volume: 22 Issue: 2
  • DOI: 10.1111/petr.13113
  • Peer Reviewed
• [Journal Article] Coexistence of Bilirubin >10 mg/dL and Prothrombin Time-International Normalized Ratio > 1.6 on Day 7: A Strong Predictor of Early Graft Loss After Living Donor Liver Transplantation. (2018)
  • Author(s): Okamura Y
  • Journal Title: Transplantation Volume: 102 Issue: 3 Pages: 440-447
  • DOI: 10.1097/tp.0000000000001959
  • Peer Reviewed
• [Journal Article] Case Report of Extensive Isolated Spontaneous Celiac Trunk Dissection After Liver Transplantation. (2017)
  • Author(s): Iwaki K
  • Journal Title: Transplant Proc. Volume: 49 Issue: 8 Pages: 1956-1959
  • DOI: 10.1016/j.transproceed.2017.06.025
  • Peer Reviewed
• [Presentation] 小腸移植における抗体関連型拒絶反応の検討 (2017)
  • Author(s): 吉澤淳
  • Organizer: 第29回日本小腸移植研究会
• [Presentation] ニーマンピック病C型に対する肝移植の1例 (2017)
  • Author(s): 吉澤淳
  • Organizer: 第35回日本肝移植研究会
• [Presentation] 小児肝移植症例の長期経過における免疫抑制療法とOperational toleranceの検討 (2017)
  • Author(s): 吉澤淳
  • Organizer: 第35回日本肝移植研究会
• [Presentation] 当院における肝芽腫に対する外科的治療方針に関して (2017)
  • Author(s): 岡本晋弥
  • Organizer: 第35回日本肝移植研究会
• [Presentation] PRETEXT III、IVで肝移植を回避できた肝芽腫肝切除症例の検 (2017)
  • Author(s): 岡本晋弥
  • Organizer: 第55回日本小児外科学会学術集会
• [Presentation] 他院から紹介された胆道閉鎖症自己肝にて肝移植待機の35歳以上患者に関して (2017)
  • Author(s): 岡本晋弥
  • Organizer: 第43回日本胆道閉鎖症研究会