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Mechanism of high malignant potential with recurrence of hepatocellular carcinoma after radiofrequency ablation

Research Project

Project/Area Number 16K19895
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionThe University of Tokushima

Principal Investigator

YAMADA Shinichiro  徳島大学, 大学院医歯薬学研究部(医学系), 徳島大学専門研究員 (30579884)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肝細胞癌 / ラジオ波焼灼療法(RFA) / HIF-1 / 癌幹細胞 / EMT / RFA / 熱刺激 / 局所再発 / 癌肝細胞 / miRNA / 温熱治療 / ラジオ波治療 / 上皮間葉転換 / microRNA / RFA後局所再発 / 熱ストレス
Outline of Final Research Achievements

Regarding radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), local recurrence is related to poor prognosis. With resected specimen, we aimed to elucidate the mechanism of high malignant potential with recurrence of hepatocellular carcinoma after radiofrequency ablation. Eighty-eight patients of HCC were divided into 2 groups; RFA group (n=10), hepatic resection was performed after local recurrence, and non-RFA group (n=78), hepatic resection was performed without prior RFA. In RFA group, mRNA of HIF-1, EpCAM, EMT marker(TGF-β, Twist, Snail-1, Vimentin), were high compared with non-RFA group. This study indicated that local recurrence after RFA accelerate HIF-1 expression, and malignant potential is enhanced through expressions of cancer stem cell and EMT markers.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Pathophysiology of recurrent hepatocellular carcinoma after radiofrequency ablation.2017

    • Author(s)
      Ikemoto T, Shimada M, Yamada S.
    • Journal Title

      Hepatology Research

      Volume: 47(1) Pages: 23-30

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial-mesenchymal transition-related genes are linked to aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation.2016

    • Author(s)
      Iwahashi S, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T, Takasu C, Saito Y, Yamada S.
    • Journal Title

      Cancer Lett

      Volume: 375(1) Issue: 1 Pages: 47-50

    • DOI

      10.1016/j.canlet.2016.02.041

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] RFA後肝細胞癌再発例はEMT誘導を介し腫瘍悪性度が増強する2016

    • Author(s)
      岩橋衆一, 島田光生, 森根裕二, 居村暁, 池本哲也, 齋藤裕, 吉川雅登, 良元俊昭, 高田厚史
    • Organizer
      第35回Microwave Surgery 研究会
    • Place of Presentation
      ホテルメルパルク熊本(熊本県熊本市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Research-status Report
  • [Presentation] RFA後肝細胞癌再発例はEMT誘導を介し腫瘍悪性度が増強する2016

    • Author(s)
      岩橋衆一, 島田光生, 森根裕二, 居村暁, 池本哲也, 齋藤裕, 石川大地, 吉川雅登, 良元俊昭, 髙田厚史
    • Organizer
      第14回日本肝がん分子標的治療研究会
    • Place of Presentation
      スペース36(大阪府大阪市)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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