Elucidation of Molecular Mechanisms of Biological Heterogeneity and Its Clinical Application in Triple-Negative Breast Cancer.
| Project/Area Number |
16K19899
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | トリプルネガティブ乳癌 / EMT / collective invasion / E-cadherin / vimentin / BRCAness / cancer invasion / heterogeneity / BRCA1 dysfunction / BRCA1プロモーターメチル化 / ゲノム不安定性 / 多様性 / BRCA1機能異常 |
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| Outline of Final Research Achievements |
The treatment of patients with TNBC has been challenging due to the absence of
these molecular targets and the heterogeneity of the disease. Multiple mechanisms have emerged to address how epithelial breast tumors invade. The aim of our study is to elucidate the clinical importance of the expression of E-cadherin and vimentin in breast cancer. Co-expression of E-cadherin and vimentin seems to be associated with the most aggressive phenotype and poorest prognosis in breast cancer. Moreover, co-localization of E-cadherin and vimentin within the same breast cancer cells indicates the existence of heterogeneity in breast cancer invasion.The therapeutic targeting of aggressive subpopulation may provide a positive impact on improving the outcomes of breast cancer patients.
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Report
(3 results)
Research Products
(15 results)
