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To develop a novel preservation solution for rat liver graft

Research Project

Project/Area Number 16K19908
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionNational Center for Child Health and Development

Principal Investigator

Shigeta Takanobu  国立研究開発法人国立成育医療研究センター, 臓器・運動器病態外科部, 医師 (60560331)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords臓器移植 / 保存液 / 臓器保存 / 肝移植 / 虚血再灌流障害 / 移植・再生医療
Outline of Final Research Achievements

In first year, we established the rat orthotopic liver transplantation model. The AST, ALT and LDH after 3 hours of reperfusion in the 6 hours or 12 hours preservation, there is no liver injury suppression effect was observed in the SS-II solution group as compared with the HTK and UW solution group. In the second year, to improve liver preservation effect, we added the histidine, PEG, MgCl2 and glutamate to the SS-II solution. As a result, survival up to 3 days was obtained in the modified SS-II solution group after 24 hours preservation. However, the survival up to 14 days was obtained in the UW solution group under the same conditions. From the above results, it was impossible to confirm the effectiveness of liver preservation using SS-II preservation solution in the rat liver transplantation model. We conclude that it seems necessary to improve the fundamental component of SS-II solution for liver organ preservation.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (9 results)

  • [Journal Article] Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation2017

    • Author(s)
      Narumoto Soichi、Sakamoto Seisuke、Uchida Hajime、Sasaki Kengo、Shigeta Takanobu、Fukuda Akinari、Nosaka Shunsuke、Irie Rie、Yoshioka Takako、Kasahara Mureo
    • Journal Title

      Pediatric Transplantation

      Volume: 22 Issue: 1

    • DOI

      10.1111/petr.13096

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimizing hepatic venous outflow reconstruction for hepatic vein stenosis with indwelling stent in living donor liver retransplantation2017

    • Author(s)
      Shigeta Takanobu、Sakamoto Seisuke、Sasaki Kengo、Uchida Hajime、Narumoto Soichi、Fukuda Akinari、Kasahara Mureo
    • Journal Title

      Pediatric Transplantation

      Volume: 21 Issue: 8

    • DOI

      10.1111/petr.13044

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Living donor liver transplantation during the first three months of life2017

    • Author(s)
      Kasahara M, Sakamoto S, Sasaki K, Uchida H, Kitajima T, Shigeta T, Narumoto S, Hirata Y, Fukuda A
    • Journal Title

      Liver Transpl

      Volume: Feb 21 Issue: 8 Pages: 1051-1057

    • DOI

      10.1002/lt.24743

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Liver Transplantation for Mitochondrial Respiratory Chain Disorder: A?Single-Center Experience and Excellent Marker of Differential Diagnosis2017

    • Author(s)
      Sasaki K.、Sakamoto S.、Uchida H.、Narumoto S.、Shigeta T.、Fukuda A.、Ito R.、Irie R.、Yoshioka T.、Murayama K.、Kasahara M.
    • Journal Title

      Transplantation Proceedings

      Volume: 49 Issue: 5 Pages: 1097-1102

    • DOI

      10.1016/j.transproceed.2017.03.065

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful resumption of peritoneal dialysis following living donor liver transplantation in children with end-stage renal disease2017

    • Author(s)
      Kanazawa Hiroyuki、Fukuda Akinari、Sato Mai、Ishimori Shingo、Sasaki Kengo、Uchida Hajime、Shigeta Takanobu、Mali Vidyadhar Padmakar、Sakamoto Seisuke、Ishikura Kenji、Kasahara Mureo
    • Journal Title

      Pediatric Transplantation

      Volume: 21 Issue: 3

    • DOI

      10.1111/petr.12897

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sequential analysis of variable markers for predicting outcomes in pediatric patients with acute liver failure.2016

    • Author(s)
      Uchida H, Sakamoto S, Fukuda A, Sasaki K, Shigeta T, Nosaka S, Kubota M, Nakazawa A, Nakagawa S, Kasahara M
    • Journal Title

      Hepatol Res

      Volume: dec 29 Issue: 12 Pages: 1241-1251

    • DOI

      10.1111/hepr.12859

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 葛西手術後胆道閉鎖症に対する生体肝移植の適応・成績と移植後予後不良因子の検討 葛西手術後胆道閉鎖症に対する生体肝移植の適応・成績と移植後予後不良因子の検討2017

    • Author(s)
      北嶋俊寛、阪本靖介、佐々木健吾、内田 孟、重田孝信、成本壮一、福田晃也、笠原群生
    • Organizer
      第72回日本消化器外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 粉砕して調製した院内製剤シロリムス散の製剤学的安定性および臨床的安全性に関する検討2017

    • Author(s)
      齊藤順平、石原里美、重田孝信、福田晃也、笠原群生、石川洋一
    • Organizer
      日本薬剤学会第32年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 各施設における抗体関連拒絶反応の経験2017

    • Author(s)
      重田孝信
    • Organizer
      ワーキンググループミーティング・脳死肝移植研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 当院における小児肝移植後胆道合併症の対策2016

    • Author(s)
      重田孝信
    • Organizer
      第33回近畿肝移植検討会
    • Place of Presentation
      大阪
    • Year and Date
      2016-12-10
    • Related Report
      2016 Research-status Report
  • [Presentation] Surginal intervention for hepatoblastoma:single center experience.2016

    • Author(s)
      Shigeta T
    • Organizer
      Asian Transplantation Week
    • Place of Presentation
      Korea
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 当院における胆道閉鎖症に対する小児生体肝移植後、成長に関与する因子の検討2016

    • Author(s)
      重田孝信
    • Organizer
      第52回日本移植学会
    • Place of Presentation
      東京
    • Year and Date
      2016-10-10
    • Related Report
      2016 Research-status Report
  • [Presentation] γGTP値が正常である小児胆汁鬱滞性肝疾患症例に対する肝移植の経験2016

    • Author(s)
      重田孝信
    • Organizer
      第33回日本小児肝移植研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
  • [Presentation] Hepatic vein(HV)reconstruction in living donoe liver re-transplantation with recurrent HV stenosis and indwelling HV stent:how to make HV anastomosis.2016

    • Author(s)
      Shigeta T
    • Organizer
      ILTS 22nd Annual International Congress
    • Place of Presentation
      Korea
    • Year and Date
      2016-05-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Pediatric living donor domino liver transplantation using explanted donor livers from maple syrup disease patients.2016

    • Author(s)
      Shigeta T
    • Organizer
      TTA Asian Regional Meeting
    • Place of Presentation
      東京
    • Year and Date
      2016-04-09
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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