| Project/Area Number |
16K19911
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | SLP-2 / stomatin / 膵癌 / 肝転移 / EMT / ミトコンドリア / 転移 / 予後因子 / 抗癌剤感受性 / Stomatin like protein 2 |
|---|
| Outline of Final Research Achievements |
Functional analysis was performed using two types of pancreatic cancer cell lines prepared by shRNA technique. We examined the susceptibility of anticancer drugs, but no significant results were obtained. However, in the cell line that suppressed the expression of SLP-2, the migratory ability and invasive ability were remarkably decreased, indicating that the EMT was controlled. In the liver metastasis model using mouse, it was shown that the number of liver metastasis was significantly decreased in the SLP-2 suppressed ccells. From the above, it is suggested that SLP-2 may regulate the invasive ability and metastasis of cancer cells via EMT.
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