• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional analysis of Stomatin like protein 2, a new prognostic factor for pancreatic cancer, and verify the relevance to prognosis

Research Project

Project/Area Number 16K19911
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

Ariake Kyohei  東北大学, 大学病院, 助教 (10754921)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsSLP-2 / stomatin / 膵癌 / 肝転移 / EMT / ミトコンドリア / 転移 / 予後因子 / 抗癌剤感受性 / Stomatin like protein 2
Outline of Final Research Achievements

Functional analysis was performed using two types of pancreatic cancer cell lines prepared by shRNA technique. We examined the susceptibility of anticancer drugs, but no significant results were obtained. However, in the cell line that suppressed the expression of SLP-2, the migratory ability and invasive ability were remarkably decreased, indicating that the EMT was controlled. In the liver metastasis model using mouse, it was shown that the number of liver metastasis was significantly decreased in the SLP-2 suppressed ccells. From the above, it is suggested that SLP-2 may regulate the invasive ability and metastasis of cancer cells via EMT.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (12 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Recurrence in Resected Pancreatic Ductal Adenocarcinoma.2018

    • Author(s)
      Ariake K, Motoi F, Shimomura H, Mizuma M, Maeda S, Terao C, Tatewaki Y, Ohtsuka H, Fukase K, Masuda K, Hayashi H, Takadate T, Naitoh T, Taki Y, Unno M
    • Journal Title

      J Gastrointest Surg

      Volume: 22(2) Issue: 2 Pages: 279-287

    • DOI

      10.1007/s11605-017-3627-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pancreatic neuroendocrine tumor with complete replacement of the pancreas by serous cystic neoplasms in a patient with von Hippel-Lindau disease: a case report2017

    • Author(s)
      Maeda S, Motoi F, Oana S, Ariake K, Mizuma M, Morikawa T, Hayashi H, Nakagawa K, Kamei T, Naitoh T, Unno M
    • Journal Title

      Surg Case Rep

      Volume: 3 Issue: 1 Pages: 105-105

    • DOI

      10.1186/s40792-017-0381-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A long-term survival case treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis2017

    • Author(s)
      Shimura M, Mizuma M, Hayashi H, Mori A, Tachibana T, Hata T, Iseki M, Takadate T, Ariake K, Maeda S, Ohtsuka H, Sakata N, Morikawa T, Nakagawa K, Naitoh T, Kamei T, Motoi F, Unno M.
    • Journal Title

      Surg Case Rep

      Volume: 3 Issue: 1 Pages: 132-132

    • DOI

      10.1186/s40792-017-0409-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Locally advanced pancreatic cancer successfully treated by distal pancreatectomy with celiac axis resection (DP-CAR) after S-1 with radiation therapy followed by gemcitabine/nab-paclitaxel therapy: a case report2017

    • Author(s)
      kyohei ariake, Fuyuhiko Motoi, Masamichi Mizuma, Keigo Murakami, Tatsuyuki Takadate, Hiedeo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Kei Nakagawa, Naoaki Sakata, Takanori Morikawa, Shimpei Maeda, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno
    • Journal Title

      Surgical Case Report

      Volume: なし Issue: 1

    • DOI

      10.1186/s40792-017-0290-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Predictive risk factors of peritoneal recurrence after surgical resection for pancreatic cancer: considering the method to prevent this dismal type of recurrence2017

    • Author(s)
      Kyohei Ariake,Fuyuhiko Motoi, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Shimpei Maeda, Tatsuyuki Takadate, Takeshi Naitoh, Shinishi Egawa, Michiaki Unno
    • Journal Title

      Surgery Today

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 肝内結石症の診断・治療2017

    • Author(s)
      有明恭平, 大塚英郎, 海野倫明
    • Journal Title

      胆石症・胆管結石 胆道炎・胆道癌 診断と治療のABC

      Volume: 121 Pages: 55-64

    • Related Report
      2016 Research-status Report
  • [Presentation] 膵癌における薬剤感受性試験(CD-DST法)が示す傾向と今後の展望について2017

    • Author(s)
      元井冬彦,水間正道,林洋毅,大塚英郎,深瀬耕司,益田邦洋,前田晋平,高館達之,中川圭,内藤剛,海野倫明
    • Organizer
      第50回制癌剤適応研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 膵癌におけるPETSUVmaxは遠隔転移再発の予測因子となる2017

    • Author(s)
      有明恭平,元井冬彦,大塚英郎,深瀬耕二,益田邦洋,高館達之,石田晶玄,水間正道,坂田直昭,中川 圭,森川孝則,林 洋毅,下村英雄,寺尾千秋,舘脇康子,江川新一,内藤 剛,海野倫明
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Predictive risk factor of liver metastasis after surgical resection for pancreatic ductal adenocarcinoma2017

    • Author(s)
      Kyohei Ariake, Fuyuhiko Motoi, Masamichi Mizuma, Hiroki Hayashi, Shimpei Maeda, Tatsuyuki Takadate, Kei Nakagawa, Takeshi Naitoh, Michiaki Unno
    • Organizer
      第29回日本肝胆膵外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of distant metastasis after curative resection for pancreatic ductal adenocarcinoma2017

    • Author(s)
      Kyohei Ariake, Kei Nakagawa, Masamichi Mizuma, Hideo Ohtsuka, Michiaki Unno
    • Organizer
      第26回日本がん転移学会学術集会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] FDG-PET SUVmaxは切除可能膵癌における術後肝転移再発の予測因子となる2017

    • Author(s)
      有明恭平,元井冬彦,水間正道,前田晋平,林洋毅,下村英雄2,寺尾千秋,高館達之,大塚英郎,深瀬耕二,益田邦洋,内藤剛,海野倫明
    • Organizer
      JDDW2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 膵癌原発巣のPETSuvmaxは予後規定因子として有用である2016

    • Author(s)
      有明恭平
    • Organizer
      JDDW2016
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 膵癌企途切症例に対する薬剤感受性試験(CD-DST法)から見た抗癌剤治療の有用性について2016

    • Author(s)
      有明恭平
    • Organizer
      第54回日本癌治療学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Predictive Risk Factors of Peritoneal Recurrence after Surgical Resection for Pancreatic Cancer: Possibility of Intraoperative Dissemination2016

    • Author(s)
      Kyohei Ariake
    • Organizer
      17th International Association of Pancreatology
    • Place of Presentation
      仙台国際会議場
    • Year and Date
      2016-08-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膵癌術後肝転移再発におけるリスク因子の検討2016

    • Author(s)
      有明恭平
    • Organizer
      第25回がん転移学会学術集会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2016-07-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 術中操作がもたらす膵癌腹膜播種再発の危険性~予防を目指した臨床研究への取り組み2016

    • Author(s)
      有明恭平
    • Organizer
      第71回日本消化器外科学会
    • Place of Presentation
      アスティ徳島
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] How to prevent the peritoneal recurrence~ considering the risk factor of peritoneal recurrence after pancreatectomy2016

    • Author(s)
      有明恭平
    • Organizer
      第28回日本肝胆膵外科学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 膵癌切除後肝転移再発症例における臨床病理学的因子の検討2016

    • Author(s)
      有明恭平
    • Organizer
      第116回日本外科学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi