Functional analysis of Stomatin like protein 2, a new prognostic factor for pancreatic cancer, and verify the relevance to prognosis
Project/Area Number |
16K19911
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | SLP-2 / stomatin / 膵癌 / 肝転移 / EMT / ミトコンドリア / 転移 / 予後因子 / 抗癌剤感受性 / Stomatin like protein 2 |
Outline of Final Research Achievements |
Functional analysis was performed using two types of pancreatic cancer cell lines prepared by shRNA technique. We examined the susceptibility of anticancer drugs, but no significant results were obtained. However, in the cell line that suppressed the expression of SLP-2, the migratory ability and invasive ability were remarkably decreased, indicating that the EMT was controlled. In the liver metastasis model using mouse, it was shown that the number of liver metastasis was significantly decreased in the SLP-2 suppressed ccells. From the above, it is suggested that SLP-2 may regulate the invasive ability and metastasis of cancer cells via EMT.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] 18-Fluorodeoxyglucose Positron Emission Tomography Predicts Recurrence in Resected Pancreatic Ductal Adenocarcinoma.2018
Author(s)
Ariake K, Motoi F, Shimomura H, Mizuma M, Maeda S, Terao C, Tatewaki Y, Ohtsuka H, Fukase K, Masuda K, Hayashi H, Takadate T, Naitoh T, Taki Y, Unno M
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Journal Title
J Gastrointest Surg
Volume: 22(2)
Issue: 2
Pages: 279-287
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Pancreatic neuroendocrine tumor with complete replacement of the pancreas by serous cystic neoplasms in a patient with von Hippel-Lindau disease: a case report2017
Author(s)
Maeda S, Motoi F, Oana S, Ariake K, Mizuma M, Morikawa T, Hayashi H, Nakagawa K, Kamei T, Naitoh T, Unno M
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Journal Title
Surg Case Rep
Volume: 3
Issue: 1
Pages: 105-105
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A long-term survival case treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis2017
Author(s)
Shimura M, Mizuma M, Hayashi H, Mori A, Tachibana T, Hata T, Iseki M, Takadate T, Ariake K, Maeda S, Ohtsuka H, Sakata N, Morikawa T, Nakagawa K, Naitoh T, Kamei T, Motoi F, Unno M.
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Journal Title
Surg Case Rep
Volume: 3
Issue: 1
Pages: 132-132
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Locally advanced pancreatic cancer successfully treated by distal pancreatectomy with celiac axis resection (DP-CAR) after S-1 with radiation therapy followed by gemcitabine/nab-paclitaxel therapy: a case report2017
Author(s)
kyohei ariake, Fuyuhiko Motoi, Masamichi Mizuma, Keigo Murakami, Tatsuyuki Takadate, Hiedeo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Kei Nakagawa, Naoaki Sakata, Takanori Morikawa, Shimpei Maeda, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno
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Journal Title
Surgical Case Report
Volume: なし
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Predictive risk factors of peritoneal recurrence after surgical resection for pancreatic cancer: considering the method to prevent this dismal type of recurrence2017
Author(s)
Kyohei Ariake,Fuyuhiko Motoi, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Masamichi Mizuma, Hiroki Hayashi, Kei Nakagawa, Takanori Morikawa, Shimpei Maeda, Tatsuyuki Takadate, Takeshi Naitoh, Shinishi Egawa, Michiaki Unno
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Journal Title
Surgery Today
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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