| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It is known that blood hypercoagulation occur after hepatectomy for liver cancer. The decrease in intrahepatic microcirculation due to blood hypercoagulation is closely related to postoperative liver failure and early recurrence of cancer. In this study, it was carried out that the use of a thrombomodulin preparation with antithrombin activity ameliorated blood hypercoagulation after hepatectomy of fatty liver mice which was susceptible to liver failure. Additionally, it was revealed that postoperative liver disorders and survival of cancer was significantly reduced.
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