• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The usability of novel serum glycobiomarker for the prognosis of acute liver failure

Research Project

Project/Area Number 16K19935
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

YOSHIYA Shohei  九州大学, 医学研究院, 共同研究員 (20717079)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肝再生 / 糖鎖 / 急性肝不全 / 予後予測 / 血清糖鎖 / バイオマーカー
Outline of Final Research Achievements

WFA+-tenascin was identified as a liver regenerating serum glycobiomarker using mouse liver regeneration model. We investigated the correlation between liver regeneration rate with 3D-CT volumetry or preserved blood specimens of living donor surgery and WFA+-tenascin, and which revealed that it is a useful liver regeneration marker in humans. In the study of liver diseases, fulminant hepatitis was high in WFA+-tenascin, and a significant positive correlation with previous prognostic prediction was found. The WFA+-tenascin value was significantly higher in the deceased group of acute liver failure cases, and the cut-off value was determined to be 5700. The usefulness as a prognostic prediction formula was examined, the specificity was 88%, sensitivity was 53%, and it was shown to be useful as prognostic prediction of acute liver failure.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Laparoscopic Left Hepatectomy for Ruptured Hepatocellular Carcinoma Controlled After Transcatheter Arterial Embolization: Case Report and Review of the Literature.2018

    • Author(s)
      Yoshiya S, Iwaki K, Sakai A, Fujita S, Kawasaki T, Yoshizumi F, Hiroshige S, Okamoto M, Fukuzawa K, Motohiro A, Maehara Y.
    • Journal Title

      In Vivo.

      Volume: 32 Issue: 3 Pages: 659-662

    • DOI

      10.21873/invivo.11290

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi