The role of tumor-associated neutrophil in the progression of hepatocellular carcinoma.
Project/Area Number |
16K19936
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
OKABE Hirohisa 熊本大学, 医学部附属病院, 助教 (40573621)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | 好中球 / 肝細胞癌 / 腫瘍関連マクロファージ / 腫瘍関連好中球 / 制御性T細胞 / CD8 T細胞 / 肝外胆管癌 / TAN |
Outline of Final Research Achievements |
Neutrophils are known as immune cells involved in biological defense against foreign substances. On the other hand, it is reported that neutrophils drive tumor progression as a tumor-associated neutrophil (TAN). The role of TAN and other immune cells in the tumor progression in hepatocellular carcinoma (HCC) is unclear. By comparing the number of immune cells in intra-tumor and extra-tumor area with HE staining, there were significantly more immune cells in extra-tumor area (p<0.001). With immunohistochemical analysis, Overall survival was significantly poor in the group with high TAN in extra-tumor area compared to the low TAN group, although TAN in intra-tumor area was not associated with prognosis. Infiltration of TAN not in intra-tumor but in the extra-tumor area may be involved in the progression of HCC. We are now working on the isolation of TAN in the peritumoral area in patients with HCC and are planning to clarify the role of it by molecular and comprehensive analysis.
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Academic Significance and Societal Importance of the Research Achievements |
本来好中球は細菌に対する生体防御に中心的に働くが、癌の進展にどのようにかかわるのかは不明である。今研究では肝細胞癌の進展において、好中球がどのように関わるかを明らかにすることを目的とした。腫瘍内と腫瘍周囲の背景肝内に存在する好中球と、根治切除後の生存率を比較すると、腫瘍内ではなく腫瘍周囲に好中球が存在する症例は切除後の生存率が不良であった。このメカニズムについて、組織中の好中球を分離し解明中である。
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Tumor-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma.2018
Author(s)
Kitano Y, Okabe H, Yamashita YI, Nakagawa S, Saito Y, Umezaki N, Tsukamoto M, Yamao T, Yamamura K, Arima K, Kaida T, Miyata T, Mima K, Imai K, Hashimoto D, Komohara Y, Chikamoto A, Ishiko T, Baba H
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Journal Title
Br J Cancer
Volume: 118(2)
Issue: 2
Pages: 171-180
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1β from activated macrophages leads to poor prognosis in pancreatic cancer.2018
Author(s)
Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, Uchihara T, Ogata Y, Nakagawa S, Okabe H, Imai K, Hashimoto D, Chikamoto A, Yamashita YI, Baba H, Ishimoto T
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Journal Title
Cancer Sci
Volume: 109(2)
Issue: 2
Pages: 462-470
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Survival impact of lymphocyte infiltration into the tumor of hepatocellular carcinoma in hepatitis B virus-positive or non-B non-C patients who underwent curative resection.2017
Author(s)
Nakagawa S, Umezaki N, Yamao T, Kaida T, Okabe H, Mima K, Imai K, Hashimoto D, Yamashita YI, Ishiko T, Chikamoto A, Baba H
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Journal Title
Hepatol Res.
Volume: 48(3)
Issue: 3
DOI
Related Report
Peer Reviewed
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[Journal Article] Shape and enhancement characteristics of pancreatic neuroendocrine tumor on preoperative contrast-enhanced computed tomography may be prognostic indicators.2017
Author(s)
Okabe H, Hashimoto D, Chikamoto A, Morikatsu Y, Taki K, Arima K, Imai K,Tamura Y, Ikeda O, Ishiko T, Uchiyama H, Ikegami T, Harimoto N, Itoh S, Yamashita Y, Yoshizumi T, Beppu T, Yamashita Y, Baba H, Maehara Y.
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Journal Title
Ann Surg Oncol
Volume: 24(5)
Issue: 5
Pages: 1399-1405
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Neutrophil-to-lymphocyte ratio predicts metachronous liver metastasis of pancreatic neuroendocrine tumors.2017
Author(s)
Arima K, Okabe H, Hashimoto D, Chikamoto A, Nitta H, Higashi T, Kaida T, Yamamura K, Kitano Y, Komohara Y, Yamashita Y, Beppu T, Takeya M, Baba H.
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Journal Title
Int J Clin Oncol
Volume: in press
Issue: 4
Pages: 734-739
DOI
Related Report
Peer Reviewed
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[Journal Article] Wnt signaling regulates hepatobiliary repair following cholestatic liver injury in mice.2016
Author(s)
Okabe H, Yang J, Sylakowski K, Yovchev M, Miyagawa Y, Nagarajan S, Chikina M, Thompson M, Oertel M, Baba H, Monga SP, Nejak-Bowen KN.
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Journal Title
Hepatology
Volume: 64(5)
Issue: 5
Pages: 1652-1666
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Diverse basis of β-catenin activation in human hepatocellular carcinoma: Implications in biology and prognosis.2016
Author(s)
Okabe H, Kinoshita H, Imai K, Nakagawa S, Higashi T, Arima K, Uchiyama H, Ikegami T, Harimoto N, Itoh S, Ishiko T, Yoshizumi T, Beppu T, Monga SP, Baba H and Maehara Y.
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Journal Title
PLoS One
Volume: 11(4)
Issue: 4
Pages: e0152695-e0152695
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Portal Vein Embolization Followed by Right-Side Hemihepatectomy for Hepatocellular Carcinoma Patients: A Japanese Multi-Institutional Study.2016
Author(s)
Beppu T, Okabe H, Okuda K, Eguchi S, Kitahara K, Taniai N, Ueno S, Shirabe K, Ohta M, Kondo K, Nanashima A, Noritomi T, Okamoto K, Kikuchi K, Baba H, FujiokaH.
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Journal Title
J Am Coll Surg.
Volume: 222
Issue: 6
Pages: 1138-1148
DOI
Related Report
Peer Reviewed
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[Journal Article] The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases.2016
Author(s)
Arima K, Okabe H, Hashimoto D, Chikamoto A, Tsuji A, Yamamura K, Kitano Y, Inoue R, Kaida T, Higashi T, Taki K, Imai K, Komohara Y, Beppu T, Takeya M, Baba H.
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Journal Title
Int J Clin Oncol.
Volume: 21(5)
Issue: 5
Pages: 940-945
DOI
Related Report
Peer Reviewed
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[Journal Article] A long survivor with local relapse of hilar cholangiocarcinoma after R1 surgery treated with chemoradiotherapy: a case report and literature review.2016
Author(s)
Okabe H, Chikamoto A, Maruno M, Hashimoto D, Imai K, Taki K, Arima K, Ishiko T, Uchiyama H, Ikegami T, Harimoto N, Itoh S, Yoshizumi T, Beppu T, Baba H, Maehara Y.
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Journal Title
Surg Case Rep
Volume: 2(1)
Issue: 1
Pages: 69-69
DOI
Related Report
Peer Reviewed
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[Journal Article] Inducible factors for cancer-associated fibroblasts in liver cancer versus myofibroblasts in inflammatory liver disease.2016
Author(s)
Okabe H, Hayashi H, Nakagawa S, Imai K, Nitta H, Arima K, Hashimoto D, Chikamoto A, Ishiko T, Beppu T, Baba H.
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Journal Title
Histol Histopathol
Volume: 31(2)
Pages: 141-8
Related Report
Peer Reviewed
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[Presentation] Clinical impact of non-alcoholic fatty liver disease in patients after curative surgery with pancreatic cancer2018
Author(s)
Hirohisa Okabe、Yo-ichi Yamashita, Shotaro Kinoshita, Rumi Itoyama, Toshihiko Yusa, Yuki Kitano, Yosuke Nakao, Shigeki Nakagawa, Katsunori Imai, Hidetoshi Nitta, Akira Chikamoto, Hideo Baba
Organizer
第64回国際外科学会日本部会総会
Related Report
Int'l Joint Research
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[Presentation] Frailty, but not sarcopenia, predicts severe postoperative complication after hepatectomy2017
Author(s)
Hirohisa Okabe、Hiromitsu Hayashi, Toshihiko Yusa, Hideaki Takeyama, Katsuhiro Ogawa, Nobuyuki Ozaki, Shinichi Akahoshi, Yoshiaki Ikuta, Kenichi Ogata, Hiroshi Takamori
Organizer
第6回アジア太平洋肝胆膵学会・第29回日本肝胆膵外科学会学術集会
Related Report
Int'l Joint Research
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