Developments of novel treatments based on inhibiting glycolysis with PPARG agonist
Project/Area Number |
16K19942
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | PPAR / GLUT1 / GLUT1阻害剤 / CDK6 / 抗癌剤感受性 / 細胞周期 / Warburg effect / 癌代謝 / PPARG / PKM2 / LDHA / シスプラチン / Glycolysis / PPARγアゴニスト / 癌糖代謝 |
Outline of Final Research Achievements |
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a tumor suppresser gene. Glucose transporter type 1 (Glut1) plays a crucial role in cancer specific metabolism to adapt to the rapid growth and tumor microenvironment. The proliferation of the esophageal squamous cell carcinoma (ESCC) cell lines were inhibited (20-70%) using small interfering (si) iRNA for GLUT1. CDK6 mRNA level significantly reduced and p27 kip mRNA level significantly increased after si-RNA for GLUT1. The anti-proliferative effect of low dose cisplatin was not detected in TE11 after control si-RNA, however low dose cisplatin exerted anti-proliferative effect after si-RNA for GLUT1. PKM2 and LDHA mRNA levels which are associated with glycolysis significantly decreased and PPARγ mRNA levels increased. The new GLUT1 inhibitor exerted a strong antitumor effect with low concentration and an additive effect with combined with cisplatin.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] Total iron-binding capacity is a novel prognostic marker after curative gastrectomy for gastric cancer.2018
Author(s)
Sawayama H, Iwatsuki M, Kuroda D, Toihata T, Uchihara T, Koga Y, Yagi T, Kiyozumi Y, Eto T, Hiyoshi Y, Ishimoto T, Baba Y, Miyamoto Y, Yoshida N, Baba H
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Journal Title
Int J Clin Oncol.
Volume: Apr 9
Issue: 4
Pages: 671-680
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic Factors of Salvage Esophagectomy for Residual or Recurrent Esophageal Squamous Cell Carcinoma After Definitive Chemoradiotherapy.2018
Author(s)
Kiyozumi Y, Yoshida N, Ishimoto T, Yagi T, Koga Y, Uchihara T, Sawayama H, Hiyoshi Y, Iwatsuki M, Baba Y, Miyamoto Y, Watanabe M, Matsuyama T, Oya N, Baba H.
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Journal Title
World J Surg.
Volume: Feb 8.
Issue: 9
Pages: 2887-2893
DOI
Related Report
Peer Reviewed
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[Journal Article] Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection. Gastric Cancer.2018
Author(s)
Kuroda D, Sawayama H, Kurashige J, Iwatsuki M, Eto T, Tokunaga R, Kitano Y, Yamamura K, Ouchi M, Nakamura K, Baba Y, Sakamoto Y, Yamashita Y, Yoshida N, Chikamoto A, Baba H
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Journal Title
Gastric Cancer.
Volume: 21(2)
Issue: 2
Pages: 204-212
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk factors for pulmonary morbidities after minimally invasive esophagectomy for esophageal cancer.2017
Author(s)
Uchihara T, Yoshida N, Baba Y, Yagi T, Toihata T, Oda E, Kuroda D, Eto T, Ohuchi M, Nakamura K, Sawayama H, Kinoshita K, Iwatsuki M, Ishimoto T, Sakamoto Y, Baba H.
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Journal Title
Surg Endosc.
Volume: Dec 22
Issue: 6
Pages: 2852-2858
DOI
Related Report
Peer Reviewed
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[Journal Article] The role of intestinal bacteria in the development and progression of gastrointestinal tract neoplasms.2017
Author(s)
Mima K, Ogino S, Nakagawa S, Sawayama H, Kinoshita K, Krashima R, Ishimoto T, Imai K, Iwatsuki M, Hashimoto D, Baba Y, Sakamoto Y, Yamashita YI, Yoshida N, Chikamoto A, Ishiko T, Baba H
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Journal Title
Surg Oncol
Volume: 26(4)
Issue: 4
Pages: 368-376
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The microbiome and hepatobiliary-pancreatic cancers.2017
Author(s)
Mima K, Nakagawa S, Sawayama H, Ishimoto T, Imai K, Iwatsuki M, Hashimoto D, Baba Y, Yamashita YI, Yoshida N, Chikamoto A, Baba H
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Journal Title
Cancer Lett.
Volume: 402
Pages: 9-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Preoperative controlling nutritional status (CONUT) is useful to estimate the prognosis after esophagectomy for esophageal cancer.2017
Author(s)
Yoshida N, Harada K, Baba Y, Kosumi K, Iwatsuki M, Kinoshita K, Nakamura K, Sakamoto Y, Miyamoto Y, Karashima R, Mima K, Sawayama H, Ohuchi M, Chikamoto A, Imamura Y, Watanabe M, Baba H
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Journal Title
Langenbeck Archiv Surg
Volume: 402(2)
Issue: 2
Pages: 333-41
DOI
Related Report
Peer Reviewed
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[Journal Article] Incidence and risk factors of synchronous colorectal cancer in patients with esophageal cancer: an analysis of 480 consecutive colonoscopies before surgery2016
Author(s)
Yoshida N, Tamaoki Y, Baba Y, Sakamoto Y, Miyamoto Y, Iwatsuki M, Shono T, Miyamoto H, Imuta M, Kurashige J, Sawayama H, Tokunaga R, Watanabe M, Sasaki Y, Yamashita Y, Baba H.
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Journal Title
Int J Clin Oncol
Volume: 6
Issue: 6
Pages: 1079-1084
DOI
Related Report
Peer Reviewed
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[Journal Article] Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis2016
Author(s)
Yamamura K, Baba Y, Nakagawa S, Mima K, Miyake K, Nakamura K, Sawayama H, Kinoshita K, Ishimoto T, Iwatsuki M, Sakamoto Y, Yamashita Y, Yoshida N, Watanabe M, Baba H.
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Journal Title
Clin Cancer Res
Volume: 22(22)
Issue: 22
Pages: 5574-5581
DOI
Related Report
Peer Reviewed
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[Journal Article] CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer.2016
Author(s)
Izumi D, Ishimoto T, Miyake K, Sugihara H, Eto K, Sawayama H, Yasuda T, Kiyozumi Y, Kaida T, Kurashige J, Imamura Y, Hiyoshi Y, Iwatsuki M, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Takamori H, Araki N, Tan P, Baba H.
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Journal Title
Int J Cancer
Volume: 1;138(5)
Issue: 5
Pages: 1207-19
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 食道扁平上皮癌におけるGlut1発現抑制による抗腫瘍効果・機序および抗癌剤感受性変化に関する検討2018
Author(s)
澤山 浩, 石本 崇胤, 吉田 直矢, 黒田 大介, 江藤 二男, 八木 泰祐, 内原 智幸, 日吉 幸晴, 岩槻 政晃, 馬場 祥史, 宮本 裕士, 馬場 秀夫
Organizer
第51回制癌剤適応研究会
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[Presentation] S状結腸癌、直腸癌に対する腹腔鏡下手術における腹腔内脂肪量と手術時間に関する検討2017
Author(s)
澤山 浩, 宮本 裕士, 日吉 幸晴, 内原 智幸, 清住 雄希, 江藤 二男, 山下 晃平, 大徳 暢哉, 岡留 一雄, 馬場 祥史, 吉田 直矢, 馬場 秀夫
Organizer
第30回日本内視鏡外科学会
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[Presentation] Inhibiting GLUT1 expression suppresses proliferation and enhances anticancer agent sensitivity in esophageal cancer2017
Author(s)
Hiroshi Sawayama, Ishimoto Takatsugu, Naoya Yoshida, Daisuke Kuroda, Tsugio Etho, Yuki Kiyozumi, Taisuke Yagi, Tomoyuki Uchihara, Yukiharu Hiyoshi, Masaaki Iwatsuki, Yoshifumi Baba, Yuji Miyamoto, Hideo Baba
Organizer
第28回消化器癌発生学会
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[Presentation] 結腸右半切除術における主リンパ節郭清術式2017
Author(s)
澤山 浩, 宮本 裕士, 日吉 幸晴, 黒田 大介, 大徳 暢哉, 江藤 二男, 清住 雄希, 八木 泰祐, 内原 智幸, 岩槻 政晃, 馬場 祥史, 吉田 直矢, 馬場 秀夫
Organizer
第42回日本大腸肛門病学会
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