Comprehensive analysis of DNA hypo methylation in Barrett's esophageal carcinoma
Project/Area Number |
16K19944
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
HARADA Kazuto 熊本大学, 医学部附属病院, 非常勤診療医師 (70608869)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 食道腺癌 / Barrett食道 / LINE-1 / DNAメチル化 / 食道腺癌部 / 正常部 / 食道癌 / バッレト食道癌 |
Outline of Final Research Achievements |
The level of long interspersed nucleotide element-1 (LINE-1) methylation has become regarded as a surrogate marker of global DNA methylation. LINE-1 methylation level was evaluated by using Bisulfite-Pyrosequencing method from frozen biopsy sample in esophageal adenocarcinoma, barrett’s esophagus and normal esophageal mucosa. We found that LINE-1 methylation level in esophageal adenocarcinoma was significantly lower than in Barrett;s esophagus and normal mucosa. Lower LINE-1 methylation group showed significantly poor prognosis compared with higher LINE-1 methylation group.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Prognostic value of LINE-1 methylation level in 321 patients with primary liver cancer including hepatocellular carcinoma and intrahepatic cholangiocarcinoma.2018
Author(s)
Miyata T, Yamashita Y, Baba Y, Harada K, Yamao T, Umezaki N, Tsukamoto M, Kitano Y, Yamamura K, Arima K, Nakagawa S, Okabe H, Imai K, Hashimoto D, Chikamoto A, Shimokawa M, Baba H
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Journal Title
Oncotarget
Volume: 9
Issue: 29
Pages: 20795-20806
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review.2017
Author(s)
Yamamura K, Kosumi K, Baba Y, Harada K, Gao F, Zhang X, Zhou L, Kitano Y, Arima K, Kaida T, Takeyama H, Higashi T, Imai K, Hashimoto D, Chikamoto A, Tan X, Baba H
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Journal Title
Surg Today
Volume: 47(12)
Issue: 12
Pages: 1450-1459
DOI
Related Report
Peer Reviewed
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