Identification of epigenetic characteristics of Cancer-associated fibroblasts
| Project/Area Number |
16K19959
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Maeda Masahiro 国立研究開発法人国立がん研究センター, 研究所, 研究員 (30738703)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | がん関連線維芽細胞 / H3K27me3 / WNT5A / エピジェネティクス / ヒストン修飾 |
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| Outline of Final Research Achievements |
Cancer-associated fibroblasts (CAFs), a major cellular component of cancer stroma, play a crucial role in cancer progression. In this study, we aimed to identify epigenetic characteristics of CAFs, which may underlie stable tumor-promoting capacities of CAFs. Primary culture of CAFs and non-CAFs was established from gastric surgical specimens. Focusing on H3K27me3, a repressive histone mark that is stable and essential for cell-specific differentiation, we revealed that CAFs had genome-wide alterations of H3K27me3, leading to aberrant production of various tumor promoting factors due to decreased H3K27me3. Among them, we identified WNT5A as a therapeutic target derived from CAFs. This study suggested that epigenetic alterations may determine CAF's biological behaviors.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me32020
Author(s)
Maeda M, Takeshima H, Iida N, Hattori N, Yamashita S, Moro H, Yasukawa Y, Nishiyama K, Hashimoto T, Sekine S, Ishii G, Ochiai A, Fukagawa T, Katai H, Sakai Y, Ushijima T
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Journal Title
Gut
Volume: 69
Issue: 2
Pages: 243-251
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Identification of therapeutic targets from cancer-associated fibroblasts by using an epigenetic approach2017
Author(s)
Masahiro Maeda, Hideyuki Takeshima, Naoko Iida, Naoko Hattori, Satoshi Yamashita, Akiko Mori, Hiroshi Moro, Genichiro Ishii, Atsushi Ochiai, Hitoshi Katai, Yoshiharu Sakai, and Toshikazu Ushijima
Organizer
第76回日本癌学会学術総会
Related Report
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